Purpose: To provide a meta-analysis of currently available literature on the topic of antibiotic prophylaxis for totally implanted venous access device (TIVAD) placement.
Materials And Methods: A systematic review of MEDLINE/PubMed was performed to identify studies that met Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria reviewing antibiotic prophylaxis in TIVAD placement. Four studies were identified that met criteria. The analysis included 2,154 patients undergoing TIVAD placement; 360 (16.7%) received antibiotic prophylaxis, and 1,794 (83.3%) received no periprocedural antibiotics.
Results: In the period after TIVAD placement, 27 (1.25%) infections were identified. Of infections, five occurred in the antibiotic prophylaxis group (1.39%), and 22 occurred in the nonprophylaxis group (1.23%) with an odds ratio of 0.84 (CI = 0.29-2.35).
Conclusions: The odds ratio of infection was 0.85 with antibiotic use but one was contained within the confidence interval suggesting no significant difference in infection rate when antibiotics were used.
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