Background: Paraquat and diquat are among the most commonly used herbicides in the world.

Objectives: Determine the magnitude, characteristics, and root causes for acute paraquat- and diquat-related illnesses in the US METHODS: Illnesses associated with paraquat or diquat exposure occurring from 1998 through 2011 were identified from the Sentinel Event Notification System for Occupational Risks (SENSOR)-Pesticides Program, the California Department of Pesticide Regulation (CDPR) Pesticide Illness Surveillance Program (PISP), and the Incident Data System (IDS). Cases identified by the National Poison Data System (NPDS) were reviewed for the years 1998-2003 and 2006-2013.

Results: A total of 300 paraquat- and 144 diquat-related acute illnesses were identified by SENSOR, PISP, and IDS. NPDS identified 693 paraquat- and 2128 diquat-related acute illnesses. In SENSOR/PISP/IDS, illnesses were commonly low severity (paraquat=41%; diquat=81%); however, SENSOR/PISP/IDS identified 24 deaths caused by paraquat and 5 deaths associated with diquat. Nineteen paraquat-related deaths were due to ingestion, seven of which were unintentional, often due to improper storage in beverage bottles. In SENSOR/PISP/IDS, paraquat and diquat-related acute illnesses were work-related in 68% (n=203) and 29% (n=42) of cases, respectively. When herbicide application site was known, the vast majority of acute paraquat-related illnesses (81%) arose from agricultural applications. Common root causes of illness were failure to use adequate personal protective equipment (PPE), application equipment failure, and spill/splash of herbicide.

Conclusions: Although the magnitude of acute paraquat/diquat-related illnesses was relatively low, several fatalities were identified. Many illnesses could be prevented through stricter compliance with label requirements (e.g. ensuring proper herbicide storage and PPE use), and through enhanced training of certified applicators.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920265PMC
http://dx.doi.org/10.1016/j.envres.2016.01.003DOI Listing

Publication Analysis

Top Keywords

diquat-related acute
12
acute illnesses
12
illnesses
10
magnitude characteristics
8
acute paraquat-
8
paraquat- diquat-related
8
diquat-related illnesses
8
paraquat diquat
8
data system
8
acute
7

Similar Publications

Metabolomics based early warning model for acute kidney injury risk in patients exposed to diquat.

Toxicol Appl Pharmacol

December 2024

Department of Hematology, The Fifth Medical Center of Chinese PLA General Hospital, No. 8 Dongda Street, Fengtai District, Beijing 100071, China. Electronic address:

Acute kidney injury (AKI) is one of the most important indications of severe clinical symptoms in patients with diquat poisoning and is closely related to poor prognosis. However, current studies have rarely focused on early warnings of diquat-related AKI, which is not conducive to the treatment of patients with early clinical diquat poisoning. In this study, untargeted plasma metabolomics was employed to reveal the differences between diquat-poisoned patients with and without AKI, as well as between patients and healthy volunteers.

View Article and Find Full Text PDF

Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases.

Clin Toxicol (Phila)

May 2022

Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Jinan, China.

Article Synopsis
  • Diquat is known to cause acute kidney injury, but its neurological effects are often overlooked, as shown in three cases of toxic encephalopathy following diquat poisoning.
  • All three patients, ranging in age from 20 to 31, ingested varying amounts of diquat, leading to severe complications including renal failure and significant neurological damage, with varying outcomes.
  • MRI findings revealed central pontine myelinolysis and toxic encephalopathy primarily affecting areas of the brain such as the pons, midbrain, and cerebellum, highlighting the serious risks associated with diquat ingestion.
View Article and Find Full Text PDF

Magnitude and characteristics of acute paraquat- and diquat-related illnesses in the US: 1998-2013.

Environ Res

April 2016

Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. Electronic address:

Background: Paraquat and diquat are among the most commonly used herbicides in the world.

Objectives: Determine the magnitude, characteristics, and root causes for acute paraquat- and diquat-related illnesses in the US METHODS: Illnesses associated with paraquat or diquat exposure occurring from 1998 through 2011 were identified from the Sentinel Event Notification System for Occupational Risks (SENSOR)-Pesticides Program, the California Department of Pesticide Regulation (CDPR) Pesticide Illness Surveillance Program (PISP), and the Incident Data System (IDS). Cases identified by the National Poison Data System (NPDS) were reviewed for the years 1998-2003 and 2006-2013.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!