Semantic memory, defined as our store of knowledge about the world, provides representational support for all of our higher order cognitive functions. As such, it is crucial that the contents of semantic memory remain accessible over time. Although memory for knowledge learned through direct observation has been investigated previously, we know very little about the retention of knowledge derived through integration of information acquired across separate learning episodes. The current research investigated cross-episode integration in 4-year-old children. Participants were presented with novel facts via distinct story episodes and tested for knowledge extension through cross-episode integration as well as for retention of the information over a 1-week delay. In Experiment 1, children retained the self-derived knowledge over the delay, although performance was primarily evidenced in a forced-choice format. In Experiment 2, we sought to facilitate the accessibility and robustness of self-derived knowledge by providing a verbal reminder after the delay. The accessibility of self-derived knowledge increased irrespective of whether participants successfully demonstrated knowledge of the integration facts during the first visit. The results suggest that knowledge extended through integration remains accessible after delays even in a population where this learning process is less robust. The findings also demonstrate the facilitative effect of reminders on the accessibility and further extension of knowledge over extended time periods.
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http://dx.doi.org/10.1016/j.jecp.2015.11.015 | DOI Listing |
Nat Rev Nephrol
July 2023
National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Complement and Inflammation Research Section (CIRS), Bethesda, MD, USA.
The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver expresses and secretes most complement components, which participate in the detection of bloodborne pathogens and drive an inflammatory reaction to safely remove the microbial or antigenic threat. However, perturbations in normal complement function can cause severe disease and, for reasons that are currently not fully understood, the kidney is particularly vulnerable to dysregulated complement activity.
View Article and Find Full Text PDFJ Immunol
October 2022
Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands;
Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, posing great social and economic burden to affected countries. Novel vaccine approaches are needed to increase protective immunity against the causative agent (Mtb) and to reduce the development of active TB disease in latently infected individuals. Donor-unrestricted T cell responses represent such novel potential vaccine targets.
View Article and Find Full Text PDFSelf-derivation of new factual knowledge is crucial for building a knowledge base. In three experiments, we investigated self-derivation about prescription medications. In Experiment 1, adults self-derived new knowledge across textual materials on 40% of trials.
View Article and Find Full Text PDFSemantic knowledge accumulates through explicit means and productive processes (e.g., analogy).
View Article and Find Full Text PDFDev Cogn Neurosci
April 2019
Department of Psychology, University of Maryland, USA.
Accumulation of semantic or factual knowledge is a major task during development. Knowledge builds through direct experience and explicit instruction as well as through productive processes that permit derivation of new understandings. In the present research, we tested the neural bases of the specific productive process of self-derivation of new factual knowledge through integration of separate yet related episodes of new learning.
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