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Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.
Sci Rep
January 2025
Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Via Ferrata 5, Pavia, Italy.
The global race against antimicrobial resistance requires novel antimicrobials that are not only effective in killing specific bacteria, but also minimize the emergence of new resistances. Recently, CRISPR/Cas-based antimicrobials were proposed to address killing specificity with encouraging results. However, the emergence of target sequence mutations triggered by Cas-cleavage was identified as an escape strategy, posing the risk of generating new antibiotic-resistance gene (ARG) variants.
View Article and Find Full Text PDFClinical and microbiological analyses of colistin-resistant strains among carbapenem-resistant complex clinical isolates.
Microbiol Spectr
December 2024
Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Carbapenem-resistant complex (CR-ECC), which is rapidly increasing as the cause of nosocomial infections, has limited treatment options. The aim of this study is to investigate the microbiological and clinical traits and molecular epidemiology of isolates of CR-ECC and provide guidance for antibiotic selection in clinical practice. Clinical CR-ECC isolates (ertapenem MIC ≥ 2 mg/L) were collected from 2021 to 2022.
View Article and Find Full Text PDFMicrobial profile and antimicrobial resistance patterns in ventilator-associated pneumonia (VAP): A cross-sectional study from Syria.
J Postgrad Med
January 2025
Department of Infectious Diseases, Damascus University- Faculty of Medicine, Damascus, Syria.
Introduction: This study aimed to determine the bacterial profile and their antibiotic spectrum in patients with ventilator-associated pneumonia (VAP) and investigate the risk factors for VAP and the presence of multidrug-resistant (MDR) pathogens.
Materials And Methods: A cross-sectional study was included 105 patients with clinically suspected VAP in intensive care units (ICUs) of two university hospitals from Syria, between January 2023 and February 2024. Culture-positive included 69 samples (65.
Intraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant : A Case Report.
Infect Dis Clin Microbiol
December 2024
Department of Anesthesiology and Critical Care Unit, Başkent University School of Medicine, Ankara, Türkiye.
Article Synopsis
- Ventriculoperitoneal shunts (VPSs) are essential for treating certain medical conditions, but they come with complications, particularly in light of increasing antibiotic resistance.
- A case was presented involving a serious VPS infection caused by bacteria resistant to colistin, which was successfully treated with intraventricular tigecycline, showing no negative side effects.
- The effectiveness of intraventricular tigecycline against colistin-resistant infections is encouraging, but more research is needed to determine proper dosages and establish guidelines for its use.
Neonatal sepsis in Vietnam: Bacterial profiles and antibiotic susceptibility in a tertiary care setting.
Am J Infect Control
December 2024
Department of Microbiology, Vietnam National Children's Hospital, Hanoi, Vietnam.
Article Synopsis
- Neonatal sepsis is a major cause of newborn deaths in low and middle-income countries, prompting a study in Vietnam to analyze bacterial causes and antibiotic resistance patterns.
- A study at the National Children's Hospital identified 202 cases of sepsis, predominantly caused by Gram-negative bacteria, with Klebsiella pneumoniae as the most common pathogen.
- The research underscores the need for ongoing monitoring and specific antibiotic strategies to effectively address neonatal sepsis and its challenges.
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