AI Article Synopsis
- - This study evaluated the effectiveness of powered air-purifying respirators (PAPRs) in reducing worker exposure to indium in sputter target manufacturing plants from 2010-2012.
- - Fifty-four workers participated, completing questionnaires and providing blood and urine samples to analyze biomarkers related to indium exposure before and after PAPRs were introduced.
- - Results showed a 6.6% penetration rate of indium inside the respirators, with significant reductions in biomarker levels indicating decreased exposure after PAPRs were implemented, highlighting their potential for improving occupational health.
Article Abstract
This study aimed to evaluate the efficacy of powered air-purifying respirators (PAPRs) worn by the workers, and to investigate the effect of this application on exposure and preclinical effects in terms of workplace measuring and biomarker monitoring in ITO sputter target manufacturing plants and workers, respectively. Fifty-four workers were recruited and investigated from 2010-2012, during which PAPRs were provided to on-site workers in September 2011. Each worker completed questionnaires and provided blood and urine samples for analysis of biomarkers of indium exposure and preclinical effects. Area and personal indium air samples were randomly collected from selected worksites and from participants. The penetration percentage of the respirator (concentration inside respirator divided by concentration outside respirator) was 6.6%. Some biomarkers, such as S-In, SOD, GPx, GST, MDA, and TMOM, reflected the decrease in exposure and showed lower levels, after implementation of PAPRs. This study is the first to investigate the efficacy of PAPRs for reducing indium exposure. The measurement results clearly showed that the implementation of PAPRs reduces levels of indium-related biomarkers. These findings have practical applications for minimizing occupational exposure to indium and for managing the health of workers exposed to indium.
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| http://dx.doi.org/10.1080/15459624.2015.1125487 | DOI Listing |
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Article Synopsis
- Indium compounds, used in mobile phone and TV displays, are linked to respiratory diseases such as interstitial pneumonia and lung cancer, but the exact causes are not fully understood.
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- Gene expression analysis showed that exposure to indium compounds notably upregulated several genes associated with inflammation, particularly S100A8 and S100A9, indicating their role in the inflammatory response to indium exposure in the lungs.*
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