This article provides the theory and application of the 2-stage maximum likelihood (ML) procedure for structural equation modeling (SEM) with missing data. The validity of this procedure does not require the assumption of a normally distributed population. When the population is normally distributed and all missing data are missing at random (MAR), the direct ML procedure is nearly optimal for SEM with missing data. When missing data mechanisms are unknown, including auxiliary variables in the analysis will make the missing data mechanism more likely to be MAR. It is much easier to include auxiliary variables in the 2-stage ML than in the direct ML. Based on most recent developments for missing data with an unknown population distribution, the article first provides the least technical material on why the normal distribution-based ML generates consistent parameter estimates when the missing data mechanism is MAR. The article also provides sufficient conditions for the 2-stage ML to be a valid statistical procedure in the general case. For the application of the 2-stage ML, an SAS IML program is given to perform the first-stage analysis and EQS codes are provided to perform the second-stage analysis. An example with open- and closed-book examination data is used to illustrate the application of the provided programs. One aim is for quantitative graduate students/applied psychometricians to understand the technical details for missing data analysis. Another aim is for applied researchers to use the method properly.
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Iran J Med Sci
December 2024
Department of Urology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran.
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Front Immunol
January 2025
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
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View Article and Find Full Text PDFWellcome Open Res
December 2024
National University of Singapore, Singapore, Singapore.
Unlabelled: Since the inception of transplantation, it has been crucial to ensure that organ or tissue donations are made with valid informed consent to avoid concerns about coercion or exploitation. This issue is particularly challenging when it comes to infants and younger children, insofar as they are unable to provide consent. Despite their vulnerability, infants' organs and tissues are considered valuable for biomedical purposes due to their size and unique properties.
View Article and Find Full Text PDFDigit Health
January 2025
Department of Exercise Rehabilitation & Welfare, Gachon University, Incheon, Republic of Korea.
Objective: Sarcopenia, a condition characterized by the progressive loss of skeletal muscle mass and strength, poses significant challenges in research due to missing data. Incomplete datasets undermine the accuracy and reliability of studies, necessitating effective imputation techniques. This study conducts a comparative analysis of three advanced methods-multiple imputation by chained equations (MICE), support vector regression, and K-nearest neighbors (KNN)-to address data completeness issues in sarcopenia research.
View Article and Find Full Text PDFDigit Health
January 2025
School of Computer Science, The University of Sydney, Sydney, NSW, Australia.
Objective: Machine learning (ML) has enabled healthcare discoveries by facilitating efficient modeling, such as for cancer screening. Unlike clinical trials, real-world data used in ML are often gathered for multiple purposes, leading to bias and missing information for a specific classification task. This challenge is especially pronounced in healthcare because of stringent ethical considerations and resource constraints.
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