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Rare and often fatal, cutaneous and renal glomerular vasculopathy (CRGV) has attracted much interest since the first UK cases were identified a decade ago. At BVA Live, David Walker will be sharing his knowledge of the disease with the aim of helping practitioners understand when CRGV should be high on their list of differential diagnoses.
View Article and Find Full Text PDFCanine cutaneous and renal glomerular vasculopathy in the Republic of Ireland: a description of three cases.
Ir Vet J
November 2019
1University College Dublin Veterinary Hospital, University College Dublin, Belfield Campus, Stillorgan Road, Dublin, Ireland.
Background: Cutaneous and renal glomerular vasculopathy (CRGV) is a condition of unknown aetiology involving microvascular thrombosis. It has recently been described in over 160 dogs in the United Kingdom and usually has a grave prognosis. To date, this condition has not been described in dogs residing in the Republic of Ireland.
View Article and Find Full Text PDFCutaneous and Renal Glomerular Vasculopathy: What Do We Know so Far?
Vet Clin North Am Small Anim Pract
July 2019
Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester SO21 2LL, UK.
Cutaneous renal glomerular vasculopathy (CRGV), colloquially named "Alabama rot," is an emerging condition in the United Kingdom, previously reported from the United States and Germany. The cause of CRGV is not yet determined; no definitive link to an infectious agent has been made. Dogs diagnosed with CRGV initially develop cutaneous lesions, and a proportion of these dogs go on to manifest acute kidney injury, which may result in oligoanuric acute renal failure.
View Article and Find Full Text PDFSignalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK.
Vet Rec
October 2018
Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK.
Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database.
View Article and Find Full Text PDFSpatiotemporal patterns and agroecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK.
Vet Rec
October 2018
Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK.
The annual outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) reported in UK dogs display a distinct seasonal pattern (November to May) suggesting possible climatic drivers of the disease. The objectives of this study were to explore disease clustering and identify associations between agroecological factors and CRGV occurrence. Kernel-smoothed maps were generated to show the annual reporting distribution of CRGV, Kuldorff's space-time permutation statistic used to identify significant spatiotemporal case clusters and a boosted regression tree model developed to quantify associations between CRGV case locations and a range of agroecological factors.
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