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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746610PMC
http://dx.doi.org/10.1038/cr.2016.3DOI Listing

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Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally important. Live cell imaging has become the leading method for chromatin dynamics tracking. However, existing CRISPR- and TALE-based genomic labeling techniques have been hampered by laborious protocols and are ineffective in labeling non-repetitive sequences.

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