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Viral Hepatitis A in 108 Adult Patients During an Eight-Year Observation at a Single Center in Poland. | LitMetric

Viral Hepatitis A in 108 Adult Patients During an Eight-Year Observation at a Single Center in Poland.

Adv Clin Exp Med

Department of Infectious Diseases, University of Medical Sciences, Poznań, Poland; Department of Infectious Diseases, Jozef Strus Multidisciplinary Municipal Hospital, Poznań, Poland.

Published: April 2016

AI Article Synopsis

  • The study analyzed data from 108 adults hospitalized for hepatitis A in Wielkopolska, Poland, from 2005 to 2013, revealing a high recovery rate of 99.1%.
  • Key risk factors included international travel and sexual activity among men, with a notable 52% of patients identifying risk factors.
  • Acalculous cholecystitis was common in patients, particularly older adults, indicating a need for awareness of this complication and the potential for active prophylaxis in at-risk populations.

Article Abstract

Background: Hepatitis A is related to significant morbidity and occasional mortality. Based on data from the Polish National Institute of Hygiene, from 2000 to 2013 a mean of 213 hepatitis A cases were reported yearly.

Objectives: The aim of the study was to assess selected data in adults hospitalized for symptomatic hepatitis A during an eight-year period in a single center in the Wielkopolska Region of Poland.

Material And Methods: All the hepatitis A patients hospitalized in the center from 2005 to 2013 were analyzed retrospectively. Data were extracted from the medical records of these individuals. The disease was confirmed by anti-HAV IgM testing.

Results: In total, 108 patients (71 men and 37 women), aged 18-65 years, were identified. All but 1 patient recovered (99.1%) and in 6 cases (5.6%) a relapse occurred. Risk factors for hepatitis A were identified in 56 patients (52%), with travel abroad being the most common one (32 patients); 19 cases were secondary and 5 patients were men who have sex with men. One hepatitis A outbreak was noted in the region during the study period. Acalculous cholecystitis was found in 33.3% of the patients who underwent abdominal ultrasound. This tended to be more common among older individuals (47.8% in patients over 40 vs. 22.6% in patients aged 18-40, p=0.0521). Patients with this finding had significantly higher mean peak ALT in comparison to those with no gallbladder abnormalities.

Conclusions: Although hepatitis A in adults is typically a benign, self-limited disease, it can occasionally have a fatal course. In a significant proportion of patients with an evident risk factor for hepatitis A, the possibility of active prophylaxis was not used. Hepatitis A should be regarded as a sexually transmitted infection. Acalculous cholecystitis is a frequent finding among adults with symptomatic hepatitis A.

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Source
http://dx.doi.org/10.17219/acem/27566DOI Listing

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