Age, weight and decompression sickness in rats.

Arch Physiol Biochem

a Laboratoire Optimisation des Régulations Physiologiques (ORPhy) , UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex , France .

Published: December 2016

Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats.

Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile.

Results: In this experiment, there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p = 0.002).

Discussion: Even with weight included in the model, age was significantly associated with DCS (p = 0.01), yet after removal of weight the association was much stronger (p = 0.002).

Conclusion: We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.

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http://dx.doi.org/10.3109/13813455.2016.1140787DOI Listing

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