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The actomyosin system is essential for the integrity of the endosomal system in bloodstream form .
Elife
November 2024
Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
The actin cytoskeleton is a ubiquitous feature of eukaryotic cells, yet its complexity varies across different taxa. In the parasitic protist , a rudimentary actomyosin system consisting of one actin gene and two myosin genes has been retained despite significant investment in the microtubule cytoskeleton. The functions of this highly simplified actomyosin system remain unclear, but appear to centre on the endomembrane system.
View Article and Find Full Text PDFStructural dynamics of the TPR domain of the peroxisomal cargo receptor Pex5 in Trypanosoma.
Int J Biol Macromol
November 2024
Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland. Electronic address:
Peroxisomal protein import has been identified as a valid target in trypanosomiases, an important health threat in Central and South America. The importomer is built of multiple peroxins (Pex) and structural characterization of these proteins facilitates rational inhibitor development. We report crystal structures of the Trypanosoma brucei and T.
View Article and Find Full Text PDFA multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei.
Int J Parasitol Drugs Drug Resist
December 2024
Chemistry and Biochemistry Department, Brigham Young University, Provo, UT, USA. Electronic address:
Kinetoplastid organisms, including Trypanosoma brucei, are a significant health burden in many tropical and semitropical countries. Much of their metabolism is poorly understood. To better study kinetoplastid metabolism, chemical probes that inhibit kinetoplastid enzymes are needed.
View Article and Find Full Text PDFA Nanobody/Monoclonal Antibody "hybrid" sandwich technology offers an improved immunoassay strategy for detection of African trypanosome infections.
PLoS Negl Trop Dis
July 2024
Laboratory for Biomedical Research, Department of Molecular Biotechnology, Environment Technology and Food Technology KR01, Ghent University Global Campus, Incheon, South Korea.
The scarcity of reliable devices for diagnosis of Animal African trypanosomiasis (AAT) presents a limitation to control of the disease. Existing high-sensitivity technologies such as PCR are costly, laborious, time-consuming, complex, and require skilled personnel. Hence, utilisation of most diagnostics for AAT is impracticable in rural areas, where the disease occurs.
View Article and Find Full Text PDFMorphological and molecular characteristics of a Trypanosoma sp. from triatomines (Triatoma rubrofasciata) in China.
Parasit Vectors
May 2024
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory on Parasite and Vector Biology, Ministry of Health; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, People's Republic of China.
Article Synopsis
- Triatomines (kissing bugs) are known carriers of trypanosomes, specifically in China, the transmission cycle of certain species like T. conorhini and Triatoma rubrofasciata is not well understood.
- Researchers conducted a study where they collected samples from Triatoma rubrofasciata to extract DNA and analyze it using microscopic and genetic methods, including sequencing and phylogenetic analysis.
- The results showed that Trypanosoma sp. present in the collected samples were closely related to T. conorhini, and laboratory tests indicated that these kissing bugs can transmit the parasite to rats and mice, albeit at low levels.
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