AI Article Synopsis
- Studies on benzene highlight the importance of assessing cancer risk from low-level exposure due to its widespread industrial use.
- Animal experiments provide more complex insights into how benzene affects humans, specifically in terms of metabolism and genotoxicity.
- Findings suggest that while higher exposures (above 30-100 ppm) lead to noticeable genotoxic effects, lower exposures may produce a linear response in DNA damage, with potential sublinear effects at very low concentrations (below 10 ppm).
Article Abstract
Considering the very large industrial usage of benzene, studies in risk assessment aimed at the evaluation of carcinogenic risk at low levels of exposure are important. Animal data can offer indications about what could happen in humans and provide more diverse information than epidemiological data with respect to dose-response consideration. We have considered experiments investigating metabolism, short-term genotoxicity tests, DNA adduct formation, and carcinogenicity long-term tests. According to the different experiments, a saturation of benzene metabolism and benzene effects in terms of genotoxicity seems evident above 30 to 100 ppm. Below 30 to 60 ppm the initiating effect of benzene seems to be linear for a large interval of dosages, at least judging from DNA adduct formation. Potential lack of a promoting effect of benzene (below 10 ppm) could generate a sublinear response at nontoxic levels of exposure. This possibility was suggested by epidemiological data in humans and is not confirmed or excluded by our observations with animals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568143 | PMC |
| http://dx.doi.org/10.1289/ehp.8982171 | DOI Listing |
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