Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1207/s15327906mbr2302_10 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
KinPred-RNA-kinase activity inference and cancer type classification using machine learning on RNA-seq data.
iScience
April 2024
Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Kinases as important enzymes can transfer phosphate groups from high-energy and phosphate-donating molecules to specific substrates and play essential roles in various cellular processes. Existing algorithms for kinase activity from phosphorylated proteomics data are often costly, requiring valuable samples. Moreover, methods to extract kinase activities from bulk RNA sequencing data remain undeveloped.
View Article and Find Full Text PDFFabrication and application of glutathione biosensing SPCE strips with gold nanoparticle modification.
RSC Adv
January 2024
Department of Biological Science and Technology, National Yang Ming Chiao Tung University Hsinchu 300 Taiwan
Glutathione (GSH) is a major antioxidant in organisms. An alteration in GSH concentration has been implicated in a number of pathological conditions. Therefore, GSH sensing has become a critical issue.
View Article and Find Full Text PDFDOSE-L1000: unveiling the intricate landscape of compound-induced transcriptional changes.
Bioinformatics
November 2023
Global Statistical Sciences, Eli Lilly, Indianapolis, IN 46285, United States.
Motivation: The LINCS L1000 project has collected gene expression profiles for thousands of compounds across a wide array of concentrations, cell lines, and time points. However, conventional analysis methods often fall short in capturing the rich information encapsulated within the L1000 transcriptional dose-response data.
Results: We present DOSE-L1000, a database that unravels the potency and efficacy of compound-gene pairs and the intricate landscape of compound-induced transcriptional changes.
Optimal Bond Constraint Topology for Molecular Dynamics Simulations of Cholesterol.
J Chem Theory Comput
March 2023
Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Max-von-Laue Straße 3, 60438 Frankfurt am Main, Germany.
We recently observed artificial temperature gradients in molecular dynamics (MD) simulations of phase-separating ternary lipid mixtures using the Martini 2 force field. We traced this artifact to insufficiently converged bond length constraints with typical time steps and default settings for the linear constraint solver (LINCS). Here, we systematically optimize the constraint scaffold of cholesterol.
View Article and Find Full Text PDFIdentification of biomarkers predictive of metastasis development in early-stage colorectal cancer using network-based regularization.
BMC Bioinformatics
January 2023
INESC-ID, Instituto Superior Técnico, Universidade de Lisboa, Rua Alves Redol 9, 1000-029, Lisbon, Portugal.
Colorectal cancer (CRC) is the third most common cancer and the second most deathly worldwide. It is a very heterogeneous disease that can develop via distinct pathways where metastasis is the primary cause of death. Therefore, it is crucial to understand the molecular mechanisms underlying metastasis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!