This paper provides the full (13) C NMR assignments for the trifluoroacetamides of five potentially appetite-reducing 5-HT2C benzazepine receptor agonists and two open-ring synthetic precursors. These compounds exist in solution as mixtures of two rotamers for each of which the (13) C NMR signals have now been assigned with the assistance of 2D NMR experiments and the carbonyl-induced shifts of the neighboring (13) CH2 resonances and long-range (13) C/(19) F couplings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mrc.4406 | DOI Listing |
Publication Analysis
Top Keywords
distinguishing rotamers
4
rotamers n-trifluoroacetyl-3-benzazepine
4
n-trifluoroacetyl-3-benzazepine derivatives
4
derivatives paper
4
paper full
4
full nmr
4
nmr assignments
4
assignments trifluoroacetamides
4
trifluoroacetamides appetite-reducing
4
appetite-reducing 5-ht2c
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!