AI Article Synopsis
- Advances in technology, particularly in molecular tools like ZFNs, TALENs, and CRISPR/Cas, have transformed the field of genome editing, essential for biological research.
- Significant progress in CRISPR/Cas technology has been made recently, enhancing its usability across various model systems.
- This review highlights developments in genome editing, emphasizing CRISPR/Cas principles, optimizations, and its applications in disease modeling and personalized medicine.
Article Abstract
Technological advances are important for innovative biological research. Development of molecular tools for DNA manipulation, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas), has revolutionized genome editing. These approaches can be used to develop potential therapeutic strategies to effectively treat heritable diseases. In the last few years, substantial progress has been made in CRISPR/Cas technology, including technical improvements and wide application in many model systems. This review describes recent advancements in genome editing with a particular focus on CRISPR/Cas, covering the underlying principles, technological optimization, and its application in zebrafish and other model organisms, disease modeling, and gene therapy used for personalized medicine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747648 | PMC |
| http://dx.doi.org/10.1016/j.gpb.2015.12.001 | DOI Listing |
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