AI Article Synopsis
- This study examines the effectiveness of a new device, the BiliCare™ bilirubinometer, for screening jaundice in infants.
- The study involved 114 paired bilirubin measurements in 93 healthy infants, showing the TCB had a consistent performance compared to serum bilirubin levels.
- Results indicate that while the device is useful for detecting jaundice, careful selection of cut-off levels is crucial due to some inaccuracies.
Article Abstract
Objective: The objective of this study is to explore the accuracy and performance of a new transcutaneous bilirubinometer (TCB) for the screening of jaundice in late preterm and term infants.
Methods: A cross-sectional study was conducted. TCB measurements were performed using the BiliCare(TM) bilirubinometer. Paired TCB and serum bilirubin (SB) measurements were analysed.
Results: One hundred and fourteen paired samples were collected from 93 healthy late preterm and term infants. Bilirubin measurements were done at median (interquartile range) of 50.5 (34, 72) hours. The mean (SD) difference between the TCB and SB was 1.87 (1.98) mg/dL. A TCB cut-off level at 8.0 mg/dL provides a sensitivity of 97.3% with a negative predictive value (NPV) of 87.5% to detect a SB level of at least 8.0 mg/dL. For SB levels of at least 10.0 mg/dL, a TCB cut-off at 9.0 mg/dL shows a sensitivity of 97.5%; NPV 95.4%. For a SB level of at least 13.0 mg/dL, a TCB cut-off at 12 or 13 mg/dL had a sensitivity of 92.9% and NPV of 98.7%.
Conclusion: The BiliCare(TM) demonstrated good performance with positive bias for the screening of jaundice in healthy late preterm or term infants. However, if adopted, proper cut-off levels should be chosen because of sub-optimal device precision.
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| http://dx.doi.org/10.3109/14767058.2016.1140141 | DOI Listing |
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