We present a case of a 28-year-old man with a severe osteoarthritic varus knee after a neglected multiligamentous injury sustained 10 years prior. Simultaneous anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstructions with high tibial osteotomy (HTO) were performed at a single stage. Five years after surgery, there were no signs of effusion and no instability, and the patient could easily kneel down without any discomfort. We think that salvage procedures and biological reconstructions would be the primary choice of surgical treatment in young patients to delay arthroplasty, and it is possible to perform simultaneous reconstructions of ACL and PCL with HTO in a single stage.
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http://dx.doi.org/10.1136/bcr-2015-210053 | DOI Listing |
Dislocation is the second most common indication for revision total hip arthroplasty (THA). In revision cases the dislocation rate can be as high as 5-30%. The aim of this study was to assess the outcome, specifically the dislocation rate in revision THA where a dual mobility cup was used.
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School of Pharmacy, Lanzhou University, Lanzhou, China.
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Sorbonne Université, CNRS, Inserm U1156, Institut de Biologie Paris Seine, Laboratoire de Biologie du Développement/UMR7622, 9 Quai St-Bernard, 75005 Paris, France.
The advent of high-throughput omics data and the generation of new algorithms provide the biologists with the opportunity to explore living processes in the context of systems biology aiming at revealing the gene interactions, the networks underlying complex cellular functions. In this article, we discuss two methods for gene network reconstruction, WGCNA (Weighted Gene Correlation Network Analysis) developed by Steve Horvath and collaborators in 2008, and MIIC (Multivariate Information-based Inductive Causation) developed by Hervé Isambert and his team in 2017 and 2024. These two methods are complementary, WGCNA generating undirected networks in which most gene-to-gene interactions are indirect, while MIIC reveals direct interactions and some causal links.
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Cawthron Institute, Nelson, New Zealand.
Intracellular, free-floating and biofilm-forming bacterial pathogens have been implicated in summer mortality of farmed Chinook salmon, Oncorhynchus tshawytscha, in New Zealand. A mortality event in 2022 in the Pelorus Sound, Marlborough, was linked to high water temperatures (> 18°C), and bacterial skin disease associated with Piscirickettsia spp. (=Rickettsia-like organisms) and Tenacibaculum species.
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Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, USA.
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