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[Microneedle combined with photodynamic therapy in the treatment of oral leukoplakia].
Beijing Da Xue Xue Bao Yi Xue Ban
February 2025
Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & NMPA Key Laboratory for Dental Materials, Beijing 100081, China.
Objective: To explore whether microneedle pretreatment can significantly improve the efficacy and safety of 5-aminolevulinic acid (ALA)-photodynamic therapy (PDT) in the treatment of oral leukoplakia.
Methods: A non-randomized controlled clinical trial was conducted. Patients with clinical and pathological diagnosis of oral leukoplakia in the Department of Oral Mucosa, Peking University School and Hospital of Stomatology were divided into experimental group and control group.
Rapid non-invasive measurement of mitochondrial oxygen tension after microneedle pre-treatment: a feasibility study in human volunteers.
J Clin Monit Comput
December 2024
Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Mitochondrial oxygen tension (MitoPO2) is a promising novel non-invasive bedside marker of circulatory shock and is associated with organ failure. The measurement of mitoPO2 requires the topical application of 5-aminolevulinc acid (ALA) to induce sufficient concentrations of the fluorescent protein protoporphyrin-IX within (epi)dermal cells. Currently, its clinical potential in guiding resuscitation therapies is limited by the long induction time prior to obtaining a reliable measurement signal.
View Article and Find Full Text PDFCombined approach of nanoemulgel and microneedle pre-treatment as a topical anticellulite therapy.
ADMET DMPK
November 2024
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Background And Purpose: Cellulite is caused by changes in the metabolism of the fatty tissue beneath the skin. Methylxanthines and retinoids are commonly added to the different anticellulite products. However, their topical permeation into the dermis is limited.
View Article and Find Full Text PDFA Combinatorial Approach with Microneedle Pretreatment and Thermosensitive Gel Loaded with Rivastigmine Lipid Nanoparticle Formulation Enables Brain Delivery via the Trigeminal Nerve.
ACS Appl Mater Interfaces
December 2024
Department of Chemistry, IPB University, Bogor 16680, West Java Indonesia.
Article Synopsis
- Alzheimer's disease leads to cognitive decline and increased care needs; Rivastigmine (RV) is a key treatment limited by the blood-brain barrier (BBB).
- A new method using polymeric microneedles (PMN) and a solid lipid nanoparticle-RV-loaded thermosensitive gel (PMN-SLN-RV-TG) shows potential for better brain delivery compared to traditional methods.
- The study found that PMN-SLN-RV-TG has improved penetration and pharmacokinetic parameters, yielding a higher brain-to-blood ratio and demonstrating safety for brain tissue, indicating a promising alternative for Alzheimer's treatment.
Combined micro-needling with topical metformin versus micro-needling with topical placebo in the treatment of melasma: a concurrent split-face study.
Arch Dermatol Res
November 2024
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
Melasma is an acquired dysfunction of melanogenesis, that poses a major therapeutic challenge and tends to recur after therapy. Several combination therapies are being tested nowadays for the treatment of melasma, with promising results. Metformin, an anti-diabetic medication, seems to inhibit melanogenesis by different mechanisms.
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