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NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control.
NPJ Aging
January 2025
Department of Developmental Biology, Department of Medicine (Joint), Washington University School of Medicine, St. Louis, Missouri, USA.
Over the past five years, systemic NAD (nicotinamide adenine dinucleotide) decline has been accepted to be a key driving force of aging in the field of aging research. The original version of the NAD World concept was proposed in 2009, providing an integrated view of the NAD-centric, systemic regulatory network for mammalian aging and longevity control. The reformulated version of the concept, the NAD World 2.
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CMAJ
January 2025
Division des maladies infectieuses (Grennan) et la British Columbia Centre for Disease Control (Grennan), University of British Columbia, Vancouver, C.-B.; Division des maladies infectieuses (Salit), University of Toronto, Toronto, Ont.; University Health Network (Salit), Toronto, Ont.
Colchicine-induced vacuolar myopathy.
CMAJ
January 2025
Departments of Neurology and Neurosurgery (Pekeles, Altman), Pediatrics (Pekeles), and Pathology (Karamchandani), McGill University; Department of Neurology (Altman), Jewish General Hospital, Montréal, Que.
Alternative models of funding curiosity-driven research.
Proc Natl Acad Sci U S A
February 2025
Department of Psychology, University of Liverpool, Liverpool L69 7ZA, United Kingdom.
Funding of curiosity-driven science is the lifeblood of scientific and technological innovation. Various models of funding allocation became institutionalized in the 20th century, shaping the present landscape of research funding. There are numerous reasons for scientists to be dissatisfied with current funding schemes, including the imbalance between funding for curiosity-driven and mission-directed research, regional and country disparities, path-dependency of who gets funded, gender and race disparities, low inter-reviewer reliability, and the trade-off between the effort and time spent on writing or reviewing proposals and doing research.
View Article and Find Full Text PDFThe misalignment of incentives in academic publishing and implications for journal reform.
Proc Natl Acad Sci U S A
February 2025
Department of Data and Decision Science, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
For most researchers, academic publishing serves two goals that are often misaligned-knowledge dissemination and establishing scientific credentials. While both goals can encourage research with significant depth and scope, the latter can also pressure scholars to maximize publication metrics. Commercial publishing companies have capitalized on the centrality of publishing to the scientific enterprises of knowledge dissemination and academic recognition to extract large profits from academia by leveraging unpaid services from reviewers, creating financial barriers to research dissemination, and imposing substantial fees for open access.
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