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Feasibility of Identifying a Female Sex Worker Cohort at High Risk of HIV Infection in the Caribbean for HIV Vaccine Efficacy Trials: Longitudinal Results of HVTN 907. | LitMetric

Feasibility of Identifying a Female Sex Worker Cohort at High Risk of HIV Infection in the Caribbean for HIV Vaccine Efficacy Trials: Longitudinal Results of HVTN 907.

J Acquir Immune Defic Syndr

*Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti;†Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA;‡Maternal and Infant Studies Center (CEMI), University of Puerto Rico School of Medicine, San Juan, PR;§Unidad de Vacunas IDCP-COIN-DIGECITSS, Santo Domingo, Dominican Republic; and‖Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD.

Published: January 2016

AI Article Synopsis

  • Identifying and retaining high-risk Caribbean women for HIV vaccine trials was challenging, but the HVTN 907 study focused on female sex workers (FSWs) to assess feasibility.
  • *The study involved 799 HIV-uninfected FSWs from Haiti, Dominican Republic, and Puerto Rico, who were assessed for risk behaviors and received counseling, with 93% retention over 18 months.
  • *Results indicated a low HIV incidence of 1.07% and a significant drop in risk behaviors over time, suggesting that future vaccine studies could effectively involve this demographic, particularly in Haiti.

Article Abstract

Background: Identifying cohorts of Caribbean women with HIV infection rates sufficient for inclusion in HIV vaccine efficacy trials has been challenging. HVTN 907 determined the feasibility of identifying and retaining a cohort of women at high risk for HIV acquisition by focusing recruitment on female sex workers (FSWs).

Methods: HIV uninfected FSWs, residing in Haiti, Dominican Republic, and Puerto Rico, who reported unprotected sex and met previously described more stringent site-specific eligibility criteria, were eligible. Behavioral risk assessment, HIV counseling and testing, and pregnancy testing were performed at baseline, 6, 12, and 18 months.

Results: Among 799 FSWs (264 from Dominican Republic, 334 from Haiti, and 201 from Puerto Rico), the median age was 26 years, with 54% having less than a high school education and 45% having a monthly household income of less than $US 100. Median number of male partners 6 months before screening was 200. Retention at 18 months was 93%. Twelve women became HIV infected, 9 from Haiti. The annualized HIV incidence was 1.07% (95% confidence interval: 0.55% to 1.87%). Pregnancy incidence was 22.5% (95% confidence interval: 21.9% to 29.5%). Statistically significant declines in risk behaviors occurred between screening and the 18-month visit assessment.

Discussion: The HVTN 907 study identified a high-risk cohort of women with excellent retention for all 3 sites, despite major challenges especially in Haiti. These results show that a bridging study of a vaccine shown to be efficacious in other clade settings would be possible among FSWs in the region, particularly in Haiti.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712715PMC
http://dx.doi.org/10.1097/QAI.0000000000000796DOI Listing

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