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Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.
Metabolomics
January 2025
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery.
View Article and Find Full Text PDFThe Effect of COVID-19 on Neonatal Outcomes in a Community Hospital.
J Clin Med
January 2025
Department of Research and Innovation, St. Luke's University Health Network, Bethlehem, PA 18015, USA.
: Despite considerable research on pregnancy outcomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the consequences for infants exposed to the virus in utero remain unclear. : A retrospective cohort study was conducted, encompassing 392 mother-infant pairs delivered between April 2020 and July 2021 at a community hospital network in northeastern Pennsylvania, USA. Of these, 198 mothers had a confirmed SARS-CoV-2 infection during pregnancy, while 194 did not.
View Article and Find Full Text PDFEffect of Health Education Intervention on Knowledge and Adherence to Intermittent Preventive Treatment of Malaria in Pregnancy Among Women.
Healthcare (Basel)
January 2025
Department of Nursing Sciences, Faculty of Basic Medical and Health Sciences, Walter Sisulu University, Nelson Mandela Drive Campus, Mthatha 5117, South Africa.
Malaria in pregnancy is a global health problem because it causes anemia in the mother and may result in abortion, stillbirth, uterine growth retardation, and low birth weight in the newborn. The purpose of this study was to assess the effects of HEI on knowledge and adherence to intermittent preventive treatment of malaria among pregnant women at secondary health facilities in Benue State, Nigeria. This quasi-experimental study included pre-, intervention, and post-intervention.
View Article and Find Full Text PDFLessons Learned in Virtual Launch of an Antenatal Opioid Exposure Study During the COVID-19 Pandemic.
Nurs Res
January 2025
RTI International, Research Triangle Park, NC.
Background: The COVID-19 pandemic prompted researchers to develop new ways to design and launch studies and recruit and retain participants. Pregnant women and infants are considered vulnerable populations in research, and families affected by substance use are particularly difficult to recruit and retain. Recruitment for studies involving medical technologies such as MRI can also be difficult due to misconceptions and fear of the technologies.
View Article and Find Full Text PDFAssociations Between Ambient PM and Thyroid Hormones in Pregnant Persons in Puerto Rico.
Toxics
January 2025
Department of Civil and Environmental Engineering, Tufts University School of Engineering, Medford, MA 02155, USA.
Introduction: This study investigates associations between fine particulate air pollution (PM) exposure and thyroid hormone levels during pregnancy in Puerto Rican individuals, a vulnerable population facing socioeconomic and environmental disparities.
Methods: This research draws on data from the PROTECT cohort study and involves 1040 participants to measure the effect of PM on developmentally important thyroid hormones (TSH, T3, T4, and FT4). Pollution concentrations were linked to participant locations using EPA air quality data and analyzed across two visits during gestational weeks 16-20 and 24-28.
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