A 52-year-old African American male with a long history of poorly controlled hypertension presented to the emergency department (ED) with two days of genital edema and pain. During ED work-up, the patient developed sudden onset of non-pitting, non-pruritic, and non-urticarial upper lip edema. Review of his antihypertensive medication list revealed that he normally took benazepril, highly suggestive of a diagnosis of angiotensin-converting-enzyme inhibitor-related angioedema (ACEI-RA). We present the first reported case of penile ACEI-RA that progressed to involve the oropharynx. The ED management of the condition and some of the newer treatment options available for ACEI-RA is also briefly discussed.
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http://dx.doi.org/10.5811/westjem.2015.8.28061 | DOI Listing |
Otolaryngol Head Neck Surg
November 2024
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
BMJ Case Rep
August 2024
Emergency Medicine, Karl Bremer Hospital, Cape Town, Western Cape, South Africa.
Int J Clin Oncol
October 2023
Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Am J Kidney Dis
August 2022
Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Chronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba, Canada. Electronic address:
Rationale & Objective: Renin-angiotensin-aldosterone system (RAAS) inhibitors are evidence-based therapies that slow the progression of chronic kidney disease (CKD) but can cause hyperkalemia. We aimed to evaluate the association of discontinuing RAAS inhibitors after an episode of hyperkalemia and clinical outcomes in patients with CKD.
Study Design: Retrospective cohort study.
Cureus
November 2021
Internal Medicine, University of Pittsburgh Medical Center McKeesport Hospital, Pittsburgh, USA.
Angioedema is one of the dreaded side effects of angiotensin-converting enzyme (ACE) inhibitors. It has been well established in the literature and the timing of onset is variable from months to years after initiation of therapy. Patients remain at risk of recurrence of angioedema even after discontinuation of the drug if they developed it once while on the drug.
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