Aims and method To explore the current salience of 'brain fag' as a nosological, diagnostic and clinical construct in modern West African psychiatry. A semi-structured questionnaire and vignette based on classical symptoms of brain fag syndrome were used to explore current knowledge, explanatory models and practice among Nigerian psychiatrists. Results Of 102 psychiatrists who responded, 98% recognised the term 'brain fag syndrome' and most recognised the scenario presented. However, only 22% made a diagnosis of brain fag syndrome in their practice preferring diagnoses of anxiety, affective and somatic disorders. Clinical implications A decreasing number of Nigerian psychiatrists are making a diagnosis of 'brain fag syndrome'. We found strong evidence of nosological and diagnostic decline in the syndrome in its place of birth. This may signal the early extinction of this disorder or nosological metamorphosis from a 'culture-bound' syndrome in West African psychiatric practice.
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http://dx.doi.org/10.1192/pb.bp.114.049049 | DOI Listing |
BMJ Open
October 2024
Department of Radiology, University of Cambridge, Cambridge, UK
Introduction: Localised renal masses are an increasing burden on healthcare due to the rising number of cases. However, conventional imaging cannot reliably distinguish between benign and malignant renal masses, and renal mass biopsies are unable to characterise the entirety of the tumour due to sampling error, which may lead to delayed treatment or overtreatment. There is an unmet clinical need to develop novel imaging techniques to characterise renal masses more accurately.
View Article and Find Full Text PDFInvest Radiol
February 2025
From the Department of Radiation Oncology, University Hospital Bonn, University of Bonn, Bonn, Germany (G.R.S., L.C.S., D.K., A.F.); Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (J.F., M. Eckl, F.S., A.R., F.A.G.); Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany (M.B.); Department of Radiology, University of Manitoba, Winnipeg, Manitoba, Canada (M. Essig); and University Medical Center Freiburg, Freiburg University, Freiburg, Germany (F.W.).
Radiology
July 2024
From the Departments of Radiology (A.S.K., K.A.P., M.A.M., J.D.K., F.A.G., T.M.), Psychiatry (J.T.O.), and Clinical Neurosciences (J.B.R.), University of Cambridge, Hills Road, Cambridge CB2 0QQ, England; and Departments of Radiology (O.I.V., F.A.G., T.M.) and Neurology (J.B.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, England.
Background Impaired glucose metabolism is characteristic of several types of dementia, preceding cognitive symptoms and structural brain changes. Reduced glucose uptake in specific brain regions, detected using fluorine 18 (F) fluorodeoxyglucose (FDG) PET, is a valuable diagnostic marker in Alzheimer disease (AD). However, the use of F-FDG PET in clinical practice may be limited by equipment availability and high cost.
View Article and Find Full Text PDFEur Radiol Exp
July 2024
Department of Radiology, University of Cambridge, Cambridge, CB2 0QQ, UK.
Background: Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and accelerated T2 mapping methods based on echo merging and using k-t undersampling and reduced flip angles (TEMPURA) and tested their potential to quantify differences between renal tumour subtypes and grades.
Methods: Twenty-four patients with treatment-naïve renal tumours were imaged: seven renal oncocytomas (RO); one eosinophilic/oncocytic renal cell carcinoma; two chromophobe RCCs (chRCC); three papillary RCCs (pRCC); and twelve clear cell RCCs (ccRCC).
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