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Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women. | LitMetric
Context : Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats.Objective : The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women.Design : The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, (41)Ca, from bone.Results : Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04).Conclusion : Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women.
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