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DNA is subject to continual damage, leaving each cell with thousands of individual DNA lesions at any given moment. The efficiency of DNA repair means that most known classes of lesion have a half-life of minutes to hours, but the extent to which DNA damage can persist for longer durations remains unknown. Here, using high-resolution phylogenetic trees from 89 donors, we identified mutations arising from 818 DNA lesions that persisted across multiple cell cycles in normal human stem cells from blood, liver and bronchial epithelium.
View Article and Find Full Text PDFUnveiling hidden reaction kinetics of carbon dioxide in supercritical aqueous solutions.
Proc Natl Acad Sci U S A
January 2025
Department of Physics, The Hong Kong University of Science and Technology, Hong Kong, China.
Dissolution of CO in water followed by the subsequent hydrolysis reactions is of great importance to the global carbon cycle, and carbon capture and storage. Despite numerous previous studies, the reactions are still not fully understood at the atomistic scale. Here, we combined ab initio molecular dynamics (AIMD) simulations with Markov state models to elucidate the reaction mechanisms and kinetics of CO in supercritical water both in the bulk and nanoconfined states.
View Article and Find Full Text PDFPotential of CoMnO spinel as soot oxidation catalyst and its kinetics thereof.
Sci Rep
January 2025
Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India.
Efficient catalysts for soot oxidation are critical for mitigating environmental pollution. In this study, CoMnO spinel catalysts were synthesised using reverse co-precipitation and co-precipitation methods to evaluate their performance in soot oxidation and kinetic behaviour. All samples exhibited a tetragonal phase (XRD) and spherical morphology with rough surfaces (SEM).
View Article and Find Full Text PDFVCP regulates early tau seed amplification via specific cofactors.
Mol Neurodegener
January 2025
Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, 6124 Harry Hines Blvd, Dallas, TX, NS8.334, United States.
Background: Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. Seeding into the complex cytoplasmic milieu happens within hours, implying the existence of unknown factors that regulate this process.
Methods: We used proximity labeling to identify proteins that control seed amplification within 5 h of seed exposure.
A Novel Polytetrahydrofuran-Based Shape Memory Polyurethane Enhanced by Polyglycolide-Block-Polytetrahydrofuran-Block-Polyglycolide Copolymer.
Polymers (Basel)
December 2024
State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
A series of polyurethanes (PU-GT) were prepared using polyglycolide-block-polytetrahydrofuran-block-polyglycolide (PGA-PTHF-PGA), polytetrahydrofuran homopolymer (PTHF), glycerol, and hexamethylene diisocyanate (HDI) by a one-pot synthesis method. The non-isothermal crystallization and subsequent heating curves showed that the PTHF component in these polyurethanes could crystallize in a temperature range of -11.5~2.
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