AI Article Synopsis
- C1q nephropathy is a rare form of glomerulonephritis primarily affecting children and young adults, characterized by dominant C1q immune deposits found in kidney biopsies.
- The disease commonly presents as nephrotic syndrome, although other renal syndromes may occur, and its cause is unknown but likely involves immune mechanisms.
- In a study of ten patients, none showed signs of systemic lupus, and all tests for complement components and specific antibodies returned normal results, indicating a unique presentation of C1q nephropathy.
Article Abstract
C1q nephropathy is considered a form of glomerulonephritis, defined by histological findings of dominant Clq immune deposits in renal biopsy. It is a rare disease, most often manifested in children and young adults. The most common clinical manifestation of the disease is nephrotic syndrome, but other renal syndromes could also be found. The cause of the disease is not known, but the immune pathogenesis could be assumed. Often, resistance to glucocorticoid or other immunosuppressive therapy is present, potentially leading to chronic renal insufficiency. We present ten patients with renal biopsy and clinical findings of Clq nephropathy. None of the patients had clinical or serological manifestations of systemic lupus. All patients had normal findings of C3 and C4 components of complement, as well as normal ANF, anti-dsD-NA and ANCA antibodies.
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