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In Vitro Antioxidant and Antibacterial Activities of Ethyl Acetate Extracts of Leaves and Five Associated Endophytic Fungi.
Microorganisms
December 2024
Laboratory of Analytic Biochemistry and Biotechnology (LABAB), Department of Biochemistry and Microbiology, Faculty of Biological and Agronomic Sciences, Mouloud Mammeri University, Tizi-Ouzou 15000, Algeria.
The exploration of new pharmacological compounds from endophytic fungi offers infinite possibilities. The aim of this study was to evaluate the antibacterial and antioxidant activities of extracts from the leaves of and five of its endophytic fungi and investigate the chemical diversity of the secondary metabolites produced. Isolated, purified, and molecularly identified endophytes and plant leaves were subjected to ethyl acetate extraction.
View Article and Find Full Text PDFEffect of Skin-to-Skin Care on the Day of Birth on Skin Colonization in Preterm Infants: A Pre- and Post-Implementation Study.
Children (Basel)
December 2024
Department of Paediatrics, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Background/objectives: Maternal skin-to-skin contact (MSSC) in neonates has been shown to reduce nosocomial infections. In preterm infants, exposure to maternal skin commensals within the first 24 h may prevent colonization by hospital-acquired pathogens. However, the impact of early MSSC on skin colonization in preterm infants is unknown.
View Article and Find Full Text PDFRevisiting Antibiotic-Impregnated Cement Spacer for Diabetic Osteomyelitis of the Foot.
Antibiotics (Basel)
December 2024
Division of Orthopedic Surgery, Rambam Health Care Campus, Haifa 3109601, Israel.
Introduction: Despite the rising global awareness and improvement of socioeconomic and living standards, the prevalence of diabetic osteomyelitis (DOM) and its complications has been increasing rapidly. This study aims to investigate the long-term prognosis of DOM of the foot treated using antibiotic-impregnated cement spacer (ACS) and the contributing risk factors for reoperation.
Methods And Materials: We retrospectively reviewed the data of 55 diabetic patients with Meggitt-Wagner Grade IIB wounds diagnosed with osteomyelitis of the foot, treated in our institution with excessive debridement, excision of the infected tissue, and implantation of antibiotic-impregnated cement spacer fixed with a Kirschner wire.
Impact of stewardship pharmacist driven MRSA nasal surveillance and de-escalation of anti-MRSA therapy (STEW PHARM MRSA NASAL SURVEILLANCE).
Antimicrob Steward Healthc Epidemiol
December 2024
Department of Pharmacy, Saint Francis Hospital and Medical Center, Hartford, CT, USA.
Objective: To determine if implementing stewardship pharmacist-driven methicillin-resistant (MRSA) nasal surveillance increases use of the test and reduces the inappropriate use of vancomycin for MRSA coverage in patients with pneumonia.
Design: Retrospective pre-/post-intervention study.
Setting: Large teaching acute care hospital.
Characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies in adults in the UK General Practice: a population-based cohort study.
J Infect
January 2025
Centre for Medicines Optimisation Research and Education, University College London Hospitals NHS Foundation Trust, London, UK; Research Department of Practice and Policy, School of Pharmacy, University College London, London, United Kingdom; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park, Hong Kong.
Objective: To assess the characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies labels in general practice in the UK.
Design: Population-based cohort study.
Setting: Primary care in the UK, 2000-2018.
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