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| http://dx.doi.org/10.1002/art.39566 | DOI Listing |
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Axial spondyloarthritis.
Lancet
January 2025
Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Germany.
Axial spondyloarthritis manifests as a chronic inflammatory disease primarily affecting the sacroiliac joints and spine. Although chronic back pain and spinal stiffness are typical initial symptoms, peripheral (ie, enthesitis, arthritis, and dactylitis) and extra-musculoskeletal (ie, uveitis, inflammatory bowel disease, and psoriasis) manifestations are also common. Timely and accurate diagnosis is challenging and relies on identifying a clinical pattern with a combination of clinical, laboratory (HLA-B27 positivity), and imaging findings (eg, structural damage on pelvic radiographs and bone marrow oedema on MRI of the sacroiliac joints).
View Article and Find Full Text PDFOutcomes of Micropulse Transscleral Cyclophotocoagulation in Uveitic Glaucoma.
Ophthalmol Ther
September 2024
Department of Ophthalmology, University of Colorado School of Medicine, 1675 Aurora Court, Aurora, CO, 80045, USA.
Article Synopsis
- The study investigates the effectiveness of micropulse transscleral cyclophotocoagulation (mpCPC) in treating uveitic glaucoma, analyzing data from six patients treated between 2015 and 2020.
- * The results show that 33.3% of eyes achieved surgical success at 6 months, which improved to 60% at 1 year, with no serious complications like persistent uveitis or hypotony reported.
- * The findings suggest mpCPC is a safe option for lowering intraocular pressure in uveitic glaucoma patients, although some may still need additional treatments.
Genetic risk factors in ankylosing spondylitis: Insights into etiology and disease pathogenesis.
Int J Rheum Dis
January 2024
Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, India.
Goodbye to the term 'ankylosing spondylitis', hello 'axial spondyloarthritis': time to embrace the ASAS-defined nomenclature.
Ann Rheum Dis
April 2024
Rheumazentrum Ruhrgebiet, Ruhr University Bochum, Herne, Germany.
Ankylosing spondylitis (AS) is the historic term used for decades for the HLA-B27-associated inflammatory disease affecting mainly the sacroiliac joints (SIJ) and spine. Classification criteria for AS have radiographic sacroiliitis as a dominant characteristic. However, with the availability of MRI of SIJ, it could be demonstrated that the disease starts long before definite SIJ changes become visible on radiographs.
View Article and Find Full Text PDFEvaluation of HLA-B*05, *07, *08, *27 and *51 Allele Expression in Adults with Immune Thrombocytopenic Purpura.
Maedica (Bucur)
March 2023
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Immune thrombocytopenic purpura (ITP) is an immune mediated acquired disease characterized by isolated thrombocytopenia. Since there is no specific and sensitive biomarkers to guide treatment of ITP patients, this study aimed to evaluate the possible application of human leukocyte alleles HLA-B5, 7, 8, 27 and 51 and their association with patients' laboratory data and clinical findings. Thirty-one adult patients with chronic ITP were included in the present study.
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