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Intravital Imaging of Leukocyte-Endothelial Interaction in Hindlimb Ischemia/Reperfusion Injury by Intravital Multiphoton Microscopy.
Methods Mol Biol
October 2023
Department of Plastic and Hand Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ischemia/reperfusion injury in skeletal muscle leads to sterile inflammation and affects structure and function permanently. However, the main understanding of the molecular and cellular mechanisms mainly relies on in vitro and ex vivo investigations. Recent advances in intravital microscopy allow for insights into dynamic processes at the cellular and subcellular level under both physiological and pathophysiological conditions.
View Article and Find Full Text PDFArticle Synopsis
- Acute renal failure in elderly patients often stems from conditions outside the kidneys, with common causes including ANCA vasculitis, light chain cast nephropathy, and drug-induced damage.
- A case study highlights a 73-year-old woman with no prior serious health issues who developed an uncommon form of acute renal failure due to medical intervention.
- Despite a biopsy that identified the cause and guided treatment, her kidney function did not fully recover, leading to chronic kidney disease stage G3bA1 with elevated serum creatinine levels.
Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs.
Heliyon
April 2023
Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Article Synopsis
- Non-traumatic acute bilateral compartment syndrome is a rare but serious condition that can cause limb ischemia, highlighted in a case involving a young woman after a five-kilometer walk while taking lurasidone.
- The patient experienced complications like bilateral foot-drop and rhabdomyolysis, but due to her late arrival at the hospital, doctors chose to monitor her condition conservatively instead of immediate surgery.
- Despite the initial severe symptoms, her health improved over time, allowing her to resume daily activities within weeks, although she still had ongoing foot-drop issues likely related to her medication and the stress of mild exercise on her muscles.
Statins Neuromuscular Adverse Effects.
Int J Mol Sci
July 2022
Unit of Neurology and Neuromuscular Disorders, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
Article Synopsis
- - Statins are commonly prescribed to high-risk patients for heart and brain health, and while they are generally safe, they can cause serious muscle-related side effects, making up about 66% of adverse reactions.
- - These side effects include muscle cramps, pain, weakness, and, in rare cases, severe conditions like rhabdomyolysis and peripheral neuropathy, which may worsen pre-existing muscle issues.
- - Ongoing patient monitoring and adjusting statin use or switching to alternative medications can help mitigate these risks, and future genetic and environmental research may lead to more personalized treatment approaches for those on statins.
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