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Comprehensive Perioperative Management of PFAPA Syndrome: Insights From Clinical Cases.
J Perianesth Nurs
January 2025
Department of Anesthesiology and Reanimation, University of Baskent, Ankara, Turkey.
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome, a common cause of recurrent fever in childhood, presents a challenge in both diagnosis and management. While initially considered a monogenic disorder, recent research has highlighted its complex genetic underpinnings, involving noncoding genome regions and immune-mediated cytokine dysregulation. This complexity underscores the need for comprehensive perioperative management strategies, particularly in surgical interventions such as tonsillectomy and adenoidectomy.
View Article and Find Full Text PDFArticle Synopsis
- The American Academy of Pediatrics released their first clinical practice guideline to help healthcare providers safely prescribe opioids for acute pain in children and adolescents, focusing on minimizing risks such as opioid use disorder and overdose.
- The guideline also highlights disparities in pain management for Black, Hispanic, and American Indian/Alaska Native youth, advocating for fair treatment across all demographics, regardless of language, socioeconomic status, or geographic location.
- It emphasizes a multimodal approach to pain management, recommending nonpharmacologic therapies and nonopioid medications, with strict guidelines for opioid prescriptions, including avoiding certain medications for specific age groups and starting with low doses and short supply durations.
Adjusting for incomplete baseline covariates in randomized controlled trials: a cross-world imputation framework.
Biometrics
July 2024
Department of Biostatistics, University of Washington, Seattle, WA 98195, United States.
In randomized controlled trials, adjusting for baseline covariates is commonly used to improve the precision of treatment effect estimation. However, covariates often have missing values. Recently, Zhao and Ding studied two simple strategies, the single imputation method and missingness-indicator method (MIM), to handle missing covariates and showed that both methods can provide an efficiency gain compared to not adjusting for covariates.
View Article and Find Full Text PDFPersistent Obstructive Sleep Apnea Post-adenotonsillectomy in Children.
Cureus
July 2024
Pediatric Pulmonology, Sidra Medicine, Doha, QAT.
Article Synopsis
- Childhood obstructive sleep apnea (OSA) is commonly caused by enlarged tonsils and adenoids, and adenotonsillectomy is the primary treatment, but some children may experience persistent OSA (POSA) afterward.
- This study examined the prevalence and risk factors of POSA in pediatric patients in Qatar by reviewing medical records of those who underwent adenotonsillectomy between 2017 and 2022.
- Out of 410 patients, 15.4% developed POSA after surgery, with significant risk factors identified including younger age, asthma, allergic rhinitis, gastroesophageal reflux disease, and genetic syndromes.
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