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A pilot study of transcriptomic preimplantation genetic testing (PGT-T): towards a new step in embryo selection?
Hum Reprod
December 2024
IVIRMA Global Research Alliance, IVI Foundation, Health Research Institute La Fe, Valencia, Spain.
Study Question: Is it possible to predict an euploid chromosomal constitution and identify a transcriptomic profile compatible with extended embryonic development from RNA sequencing (RNA-Seq) data?
Summary Answer: It has been possible to obtain a karyotype comparable to preimplantation genetic testing for aneuploidy (PGT-A), in addition to a transcriptomic signature of embryos which might be suggestive of improved implantation capacity.
What Is Known Already: Conventional assessment of embryo competence, based on morphology and morphokinetic, lacks knowledge of molecular aspects and faces controversy in predicting ploidy status. Understanding the embryonic transcriptome is crucial, as gene expression influences development and implantation.
How does air quality affect the health of children and adolescents?
J Pediatr (Rio J)
December 2024
Universidade Federal do Paraná (UFPR), Curitiba, Paraná, Brazil.
Objectives: To assess how air quality and pollutants affect the health of children and adolescents.
Source Of Data: A narrative review of recent literature was conducted using PubMed databases, focusing on studies published between 2015 and 2023. The keywords included "air pollution", "child health", "adolescents", "respiratory diseases" and "cognitive development".
Genetic investigations into the use of sensory evaluation: The case of boar taint discrimination in Pietrain sired crossbreds.
J Anim Sci
December 2024
TERRA Teaching and Research Center, University of Liège, Gembloux Agro-Bio Tech (ULiège-GxABT), 5030 Gembloux, Belgium.
Using genetic selection for raising intact boars, which improves growth and feed efficiency, is a promising alternative to castration for mitigating boar taint. Selective breeding has the potential to help to identify and select for genetic lines with a reduced risk of boar taint. Common phenotypes are laboratory measurements of skatole (SKA) and androstenone (ANON) i.
View Article and Find Full Text PDFAbstractThe ability to secure food for offspring and withstand the cost of reproduction favors high-quality mothers that overproduce the larger sex, typically sons, only if they will receive adequate food, as this should enhance these sons' fitness returns. However, high-quality daughters ensure that grandoffspring receive quality parental care and may possess greater reproductive value than their brothers, favoring daughters also from high-quality mothers. Using a mixed cross-fostering approach, we investigated effects of early rearing conditions, covariance between breeders and their genetic parents in parental quality, and primary offspring sex ratios in Carolina wrens.
View Article and Find Full Text PDFFuncFetch: An LLM-assisted workflow enables mining thousands of enzyme-substrate interactions from published manuscripts.
Bioinformatics
December 2024
Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, United States.
Motivation: Thousands of genomes are publicly available, however, most genes in those genomes have poorly defined functions. This is partly due to a gap between previously published, experimentally-characterized protein activities and activities deposited in databases. This activity deposition is bottlenecked by the time-consuming biocuration process.
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