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Prevalence of common conditions and associated mortalities of dogs treated at the small animal clinic, Makerere University, Kampala, Uganda.
BMC Vet Res
December 2024
School of Statistics and Planning, Makerere University, Kampala, Uganda.
Background: In developing countries such as Uganda, domestic dogs suffer high burdens of infectious diseases often with high mortalities. Surveillance data on the common diseases and associated mortalities is however scanty. We thus, present results of a retrospective study of common clinical conditions and mortalities of dogs brought for treatment at the small animal clinic, Makerere University, Kampala, Uganda.
View Article and Find Full Text PDFChemical and Heat Treatment for Viral Inactivation in Porcine-Derived Gelatin.
BMC Biotechnol
December 2024
Biomedical Department, R&D Center, Nitta Gelatin Inc, 2-22, Futamata, Yao City, Osaka, 581-0024, Japan.
Article Synopsis
- - The study focuses on evaluating the effectiveness of virus inactivation methods used in the manufacturing process of porcine-derived gelatin, which is commonly used in pharmaceuticals and medical devices.
- - Researchers tested various model viruses and found that both chemical and heat treatments significantly reduced viral presence, achieving a log reduction value (LRV) greater than 4, indicating effective inactivation.
- - The findings confirm that implementing these treatment steps in gelatin production enhances safety by minimizing potential viral contamination in biomedical applications.
Detection and molecular epidemiology of canine parvovirus and identification of highly pathogenic CPV-2c isolates from Shandong, China.
Virus Genes
December 2024
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
Article Synopsis
- Canine parvovirus (CPV) is a serious virus affecting dogs and wild carnivores, with high mutation rates making it a challenging pathogen.
- A study in Shandong involved testing 62 samples from sick dogs, finding a 62.9% positivity rate for CPV, with the majority being subtype CPV-2c.
- Researchers identified new mutations in the virus that could affect how it interacts with hosts and its vaccine efficacy, and one particularly dangerous strain was isolated and found to be fatal to dogs in animal tests.
Molecular detection and quantification of canine parvovirus 2 using a fast and sensitive SYBR green-based quantitative polymerase chain reaction assay in dogs affected with gastroenteritis.
Vet World
October 2024
Facultad de Ciencias de la Salud, Carrera de Medicina Veterinaria, Universidad de Las Américas (UDLA), Quito, Ecuador, Antigua Vía a Nayón S/N, Quito EC 170124, Ecuador.
Background And Aim: Viral gastroenteritis in canines is primarily caused by the canine parvovirus 2 (CPV-2). Infections by this virus can cause severe consequences in dogs, such as fever, vomiting, diarrhea, septicemia, systemic inflammation, and immunosuppression. Therefore, the mortality rate of persistent infections caused by this virus is significantly high.
View Article and Find Full Text PDFCanine parvovirus NS1 induces host translation shutoff by reducing mTOR phosphorylation.
J Virol
November 2024
Guangdong Technological Engineering Research Center for Pets, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China.
Unlabelled: Canine parvovirus type 2 (CPV-2) is a member of the Parvoviridae family, characterized by its small, non-enveloped virions containing a linear single-stranded DNA genome of approximately 5 kb. Parvoviruses entirely reliant on the host cell's division machinery for replication. In this study, we demonstrate that CPV-2 infection triggers the host translation shutoff, a process in which the nonstructural protein 1 (NS1) plays a pivotal role.
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