AI Article Synopsis
- Researchers synthesized three series of indeno[1,2-c]isoquinolines with a ferrocenyl component to explore their effects on DNA interactions and cancer cell inhibition.
- The ferrocenyl was strategically placed either as a linker between nitrogen atoms or at the end of a carbon chain to assess its influence on topoisomerase I and II inhibition.
- Results indicated that the ferrocenyl addition improved topoisomerase II inhibition, and many compounds exhibited significant growth inhibition against the MDA-MB-231 breast cancer cell line, with IC50 values in the micromolar range.
Article Abstract
Three series of indeno[1,2-c]isoquinolines bearing a ferrocenyl entity were synthesized and evaluated for DNA interaction, topoisomerase I and II inhibition, and cytotoxicity against breast human cancer cell lines. In the first and second series, the ferrocenyl scaffold was inserted as a linker between the two nitrogen atoms. In the last series, it was introduced at the end of the carbon chain. The present study showed that the ferrocenyl entity enhanced the topoisomerase II inhibition. Most compounds showed a potent growth inhibitory effect on MDA-MB-231 cell line with the IC50 in μM range.
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| http://dx.doi.org/10.1016/j.bmc.2015.12.033 | DOI Listing |
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