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Development of a fast dissolving film of epinephrine hydrochloride as a potential anaphylactic treatment for pediatrics. | LitMetric

AI Article Synopsis

Article Abstract

Objective: To develop a fast dissolving film strip containing epinephrine HCl for the potential treatment of pediatric anaphylaxis.

Methods: Four different films have been prepared by solvent casting technique where the percentages of the polymer (Lycoat RS720) were optimized. The polymer percentages were (20%, 25%, 27% and 30%) of the total formulation weighs. The thickness and elastic modulus of the optimized film was evaluated using dynamic mechanical analyzer. Epinephrine content uniformity was assessed using UV at wavelength 280 nm. For the dissolution test, fast dissolving films (FDFs) were evaluated in 500 Simulated Saliva, with 50 rpm. In vivo taste and disintegration evaluation was performed on six healthy volunteers.

Results: Films formed by formulations 1, 2 and 3 were too sticky after drying, while formulation 4 that has 30% polymer content formed smooth, transparent, flexible and uniform film, and therefore, it was selected for further testing. The value of elastic modulus was determined at 1.325 MPa. The thickness of the film at different locations was measured at 0.29 mm. Drug content in film was measured at 93% ±10. More than 90% of epinephrine was released from the film within 7.2 min. Bitterness of epinephrine was masked efficiently according to volunteer's comments with average disintegration time of 20 s.

Conclusion: This study presents potential proof for using FDFs as a replacement therapy of epinephrine injections for pediatrics.

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Source
http://dx.doi.org/10.3109/10837450.2015.1131715DOI Listing

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