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Separate and combined blockades of α- and β-adrenergic receptors in forearm sweating induced by adrenergic agents and exercise in the heat in young adults.
Am J Physiol Regul Integr Comp Physiol
February 2025
Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.
The assessment of adrenergic modulation of sweating as assessed via pharmacologic administration of α- and β-adrenergic receptor blockers during exercise has yielded mixed findings. However, the underlying mechanisms for this disparity remain unresolved. We investigated the effects of separate and combined blockade of α- and β-adrenergic receptors on forearm sweating induced by a 30-min moderate-intensity exercise bout ( = 17, ) and the administration of adrenergic agonists epinephrine and norepinephrine ( = 16, ) in the heat.
View Article and Find Full Text PDFUnexpected pheochromocytoma leading to cardiac arrest during the perioperative period: a case report and literature review.
BMC Anesthesiol
December 2024
Department of Anaesthesiology, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang, 322000, China.
Background: Pheochromocytomas (PCCs) are rare neuroendocrine catecholamine (CA)-secreting tumours that originate from chromaffin tissue and can produce and store CAs. Unexpected PCCs pose a serious threat to the perioperative safety of patients and a considerable challenge to anaesthesiologists because of the risks of fatal hypertensive crises and other stresses.
Case Presentation: A 37-year-old woman who was scheduled for tonsillectomy and palatopharyngoplasty under general anaesthesia experienced a malignant cardiovascular event after induction, which was characterized mainly by a sharp increase in heart rate and blood pressure, ultimately leading to cardiac arrest and the occurrence of secondary long QT syndrome.
Percutaneous Microwave Ablation for Aldosterone-Producing Adenoma.
J Vasc Interv Radiol
December 2024
Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:
Thirty-five patients diagnosed with aldosterone-producing adenomas (APAs) underwent computed tomography (CT)-guided percutaneous microwave ablation (MWA). Comparisons of aldosterone-to-renin ratio, potassium level, blood pressure (BP), and medications were performed preprocedurally, postprocedurally, and at the latest follow-up examination. The outcome assessment was based on the Primary Aldosteronism Surgical Outcome (PASO) standards.
View Article and Find Full Text PDFSerotonin 1A Receptors Modulate Serotonin 2A Receptor-Mediated Behavioral Effects of 5-Methoxy-,-dimethyltryptamine Analogs in Mice.
ACS Chem Neurosci
December 2024
Designer Drug Research Unit, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, United States.
5-methoxy-,-dimethyltrytpamine (5-MeO-DMT) analogs are used as recreational drugs, but they are also being developed as potential medicines, warranting further investigation into their pharmacology. Here, we investigated the neuropharmacology of 5-MeO-DMT and several of its -alkyl, -allyl, and 2-methyl analogs, with three major aims: 1) to determine in vitro receptor profiles for the compounds, 2) to characterize in vitro functional activities at serotonin (5-HT) 2A receptors (5-HT) and 1A receptors (5-HT), and 3) to examine the influence of 5-HT on 5-HT-mediated psychedelic-like effects in the mouse head twitch response (HTR) model. In vitro receptor binding and functional assays showed that all 5-MeO-DMT analogs bind with high affinity and activate multiple targets (e.
View Article and Find Full Text PDFPresentation, Management, and Outcomes of Patients with Giant Pheochromocytoma: Retrospective Cohort Study.
J Clin Endocrinol Metab
September 2024
Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, 55905, USA.
Context: Data on giant pheochromocytomas (PHEO), defined based on size ≥ 10 cm, are scarce.
Objective: to compare presentation, management, and outcomes of patients with giant vs non-giant PHEOs.
Design: retrospective cohort study, 2000-2023.
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