AI Article Synopsis
- The study aimed to assess the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) using optical coherence tomography (OCT) in patients with normal-tension glaucoma (NTG) and Alzheimer disease (AD), compared to healthy individuals.
- Results showed that both NTG and AD patients had significantly reduced RNFL and GCC thickness, along with increased global loss volume (GLV) compared to controls; however, no significant differences were found between the NTG and AD groups.
- The findings suggest that measuring RNFL and GCC thickness, as well as GLV rates, could aid in diagnosing AD and offer insights into the disease's progression.
Article Abstract
Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects.
Materials And Methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients.
Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG and AD patients when compared to the control subjects (P = 0.004, P = 0.006, P < 0.001, respectively). The statistical evaluation showed no difference in any RNFL or GCC parameters between the AD and NTG groups (P > 0.05). There was a negative correlation between disease duration and average RNFL and GCC thicknesses (r = -0.350, P = 0.027 and r = -0.471, P = 0.002, respectively) and a positive correlation between duration and GLV (r = 0.427, P = 0.006) in the AD group.
Conclusion: The average RNFL thickness, GCC thickness, and GLV rates may help in the diagnosis of AD as an additional examination and may provide some important clues about the duration of the disease.
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| http://dx.doi.org/10.3906/sag-1406-145 | DOI Listing |
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