Knowing the arterial geometry might be helpful in the assessment of a plaque rupture event. We present a proof of concept study implementing a novel method which can predict the evolution in time of the atheromatic plaque in carotids using only statistical features which are extracted from the arterial geometry. Four feature selection methods were compared: Quadratic Programming Feature Selection (QPFS), Minimal Redundancy Maximal Relevance (mRMR), Mutual Information Quotient (MIQ) and Spectral Conditional Mutual Information (SPECCMI). The classifier used is the Support Vector Machines (SVM) with linear and Gaussian kernels. The maximum accuracy that was achieved in predicting the variation in the mean value of the Lumen distance from the centerline and the thickness was 71.2% and 70.7% respectively.
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http://dx.doi.org/10.1109/EMBC.2015.7319895 | DOI Listing |
J Biomech
December 2024
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, United States of America.
Medical image-based diagnostic techniques have become increasingly common in the clinic. Estimating fractional flow reserve in coronary stenoses from medical image data is among the most prominent examples. The modeling techniques used in these clinical tools require rigorous experimental validation yet there is currently no standardized, public toolset to help assess model credibility.
View Article and Find Full Text PDFUps J Med Sci
January 2025
Centre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, Sweden.
Background: Growth differentiation factor 15 (GDF-15) is a robust prognostic biomarker in patients with cardiovascular (CV) disease, and a better understanding of its clinical determinants is desirable. We aimed to study the associations between GDF-15 levels and in outpatients with peripheral arterial disease (PAD).
Methods: An explorative cross-sectional study (Study of Atherosclerosis in Vastmanland, Västerås, Sweden) included 439 outpatients with carotid or lower extremity PAD.
Int J Numer Method Biomed Eng
January 2025
Department of Mathematics, University of Trento, Trento, Italy.
The main objectives of this work are to validate a 1D-0D unsteady solver with a distributed stenosis model for the patient-specific estimation of resting haemodynamic indices and to assess the sensitivity of instantaneous wave-free ratio (iFR) predictions to uncertainties in input parameters. We considered 52 patients with stable coronary artery disease, for which 81 invasive iFR measurements were available. We validated the performance of our solver compared to 3D steady-state and transient results and invasive measurements.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK.
Cardiovascular diseases (CVDs) are the most common health threats worldwide. 2D X-ray invasive coronary angiography (ICA) remains the most widely adopted imaging modality for CVD assessment during real-time cardiac interventions. However, it is often difficult for the cardiologists to interpret the 3D geometry of coronary vessels based on 2D planes.
View Article and Find Full Text PDFBioengineering (Basel)
November 2024
University of Electronic Science and Technology of China, Chengdu 611731, China.
Aneurysm modeling and simulation play an important role in many specialist areas in the field of medicine such as surgical education and training, clinical diagnosis and prediction, and treatment planning. Despite the considerable effort invested in developing computational fluid dynamics so far, visual simulation of blood flow dynamics in aneurysms, especially the under-explored aspect of bifurcation aneurysms, remains a challenging issue. To alleviate the situation, this study introduces a novel Smoothed Particle Hydrodynamics (SPH)-based method to model and visually simulate blood flow, bifurcation progression, and fluid-structure interaction.
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