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Abiotic and Biotic Dissipation in Natural Attenuation of Phenanthrene and Benzo[a]pyrene: A Systematic Quantification Study in Contrasting Soils.
Environ Pollut
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
Natural attenuation represents a significant ecosystem function for mitigating the quantity and toxicity of polycyclic aromatic hydrocarbons (PAHs) through both abiotic and biotic dissipation processes. This study systematically investigated abiotic and biotic dissipation of phenanthrene (Phe) and benzo[a]pyrene (BaP) in four soils over 360 days, using CSIA to quantitatively analyze δ³C changes and demonstrate biodegradation. The results indicated that extractable Phe was primarily attenuated via biodegradation (65% - 81%), as revealed by CSIA, with the δ³C changes ranging from 2.
View Article and Find Full Text PDFQuantifying crystallinity of amlodipine maleate in amorphous solid dispersions produced by fluidized bed granulation using PAT tools.
Eur J Pharm Sci
January 2025
Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia; KRKA, d. d., 8501 Novo Mesto, Slovenia. Electronic address:
One of the main concerns with formulations containing amorphous solid dispersions (ASDs) is their physical stability. Stability can be compromised if a formulation contains any residual crystallinity of an active pharmaceutical ingredient (API) that could act as seeds for further crystallisation. This study presents four methods for crystalline amlodipine maleate quantification in ASD, which were developed using one Raman and three NIR process analysers.
View Article and Find Full Text PDFDevelopment and validation of a UPLC-MS/MS method for simultaneous quantification of polymyxins and caspofungin in human plasma for therapeutic drug monitoring.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
School of Pharmacy, Lanzhou University, Lanzhou 730030 China; Department of Pharmacy, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030 China. Electronic address:
Objective: To develop a rapid, convenient, accurate, and low-residual-effect ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of polymyxin B sulfate and colistin sulfate in the blood of patients with multidrug-resistant bacterial infections, as well as caspofungin acetate in the blood of patients with fungal infections, thus facilitating the rational use of antibiotics in clinical applications.
Methods: All analytes were diluted with 0.2 % aqueous formic acid, and plasma proteins were precipitated using acetonitrile.
CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally.
Cell Syst
January 2025
Department of Biochemistry & BioFrontiers Institute, University of Colorado, Boulder, CO 80303, USA. Electronic address:
The mitogen-activated protein kinase (MAPK) pathway integrates growth factor signaling through extracellular signal-regulated kinase (ERK) to control cell proliferation. To study ERK dynamics, many researchers use an ERK activity kinase translocation reporter (KTR). Our study reveals that this ERK KTR also partially senses cyclin-dependent kinase 2 (CDK2) activity, making it appear as if ERK activity rises as cells progress through the cell cycle.
View Article and Find Full Text PDFHealth risk assessment of ciprofloxacin, tetracycline, and oxytetracycline residues in raw, frozen, and boiled broiler chicken available in a local area of Bangladesh.
Front Antibiot
April 2024
Department of Food Technology and Nutritional Science, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Introduction: The misuse of antibiotics in poultry farming is a global issue.
Objective: The focus of this study was the health risk assessment of consumers from the determination of ciprofloxacin (CIP), tetracycline (TC), and oxytetracycline (OTC) in broiler chicken in the raw, frozen, and boiled stages using solid-phase extraction, high-performance liquid chromatography, and ultraviolet detection (SPE-HPLC-UV).
Materials And Methods: Chromatographic separation was achieved using 0.
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