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http://dx.doi.org/10.1080/15384101.2015.1130091 | DOI Listing |
Cell Cycle
December 2016
a Department of Biochemistry , University of Lausanne, Epalinges , Switzerland.
Nat Cell Biol
September 2015
Department of Biochemistry, University of Lausanne, Epalinges CH-1066, Switzerland.
Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in dermal fibroblasts is sufficient for CAF activation and ensuing keratinocyte-derived tumours.
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