AI Article Synopsis
- - The study focuses on improving gelatin nanofibers by using an in situ cross-linked electrospinning technique, incorporating graphite oxide to enhance their properties.
- - The resulting Gel-GO nanofibers demonstrate better mechanical strength and hydrolysis resistance, while slightly lower moisture absorption and retention compared to traditional gelatin nanofibers.
- - These enhanced Gel-GO nanofibers show promise for applications in drug delivery and skin tissue engineering due to their improved biocompatibility and structural integrity.
Article Abstract
Electrospun gelatin(Gel) nanofibers scaffold has such defects as poor mechanical property and quick degradation due to high solubility. In this study, the in situ cross-linked electrospinning technique was used for the production of gelatin nanofibers. Deionized water was chosen as the spinning solvent and graphite oxide (GO) was chosen as the enhancer. The morphological structure, porosity, thermal property, moisture absorption, and moisture retention performance, hydrolysis resistance, mechanical property, and biocompatibility of the produced nanofibers were investigated. Compared with in situ cross-linked gelatin nanofibers scaffold, in situ cross-linked Gel-GO nanofibers scaffold has the following features: (1) the hydrophilicity, moisture absorption, and moisture retention performance slightly reduce, while the hydrolysis resistance is improved; (2) the breaking strength, breaking elongation, and Young's modulus are significantly improved; (3) the porosity slightly reduces while the biocompatibility considerably increases. The in situ cross-linked Gel-GO nanofibers scaffold is likely to be applied in such fields as drug delivery and scaffold for skin tissue engineering.
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| http://dx.doi.org/10.1080/09205063.2015.1133156 | DOI Listing |
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