AI Article Synopsis
- The study aimed to assess how effective two antibiotics, chloramphenicol (CHL) and ciprofloxacin (CIP), are against strains of Bartonella bacilliformis in Peru using three laboratory testing methods.
- Out of 100 strains tested, 26% were resistant to CIP while only 1% showed resistance to CHL, with consistent results across all testing methods.
- The findings suggest that there is a significant resistance issue with CIP, highlighting the need for further research into treatment options for Bartonellosis, and established that E-test and disk diffusion are reliable methods for measuring antibiotic effectiveness.
Article Abstract
Objectives: To evaluate in vitro antimicrobial susceptibility to chloramphenicol (CHL) and ciprofloxacin (CIP) in strains of Bartonella bacilliformis from areas that are endemic to Bartonellosis in Peru, through three laboratory methods.
Materials And Methods: Antimicrobial susceptibility to CHL and CIP from 100 strains of Bartonella bacilliformis isolated in patients from the regions of Ancash, Cusco, Cajamarca, Lima and La Libertad were evaluated. Strains were evaluated by: disk diffusion, E-test and agar dilution.
Results: 26% of the strains of Bartonella bacilliformis evaluated were resistant to CIP and 1% to CHL. Similar patterns of antimicrobial sensitivity / resistance were obtained in all three methods.
Conclusions: Bartonella bacilliformis strains circulating in Peru have high levels of in vitro resistance to CIP, so it is advisable to expand research on the use of drug treatment regimens of the Bartonellosis. The methods of E-test and disk diffusion were the most suitable for assessment in vitro of antimicrobial susceptibility of the microorganism.
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