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Generational Differences in Self-Esteem and Vocal Perception Among Brazilian Gay Men.
J Voice
January 2025
Speech-Language Pathology Department, Universidade Federal de São Paulo - UNIFESP, Rua Botucatu, 802 Vila Clementino, 04023-062, São Paulo, São Paulo, Brazil. Electronic address:
Introduction: Self-esteem and vocal perception are central aspects of identity and self-presentation, particularly within marginalized communities where voice and self-concept can be deeply intertwined with social acceptance and cultural dynamics. Among Brazilian gay men, generational differences in these areas may reflect broader social changes, shifts in stigma, and evolving notions of masculinity. This study aims to explore these differences, examining how self-esteem and self-assessed vocal descriptions vary across generations, thereby shedding light on specific needs and areas for potential support within these communities.
View Article and Find Full Text PDFLinking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer.
ESMO Open
January 2025
Translational Genomics and Targeted Therapies in Solid Tumors group, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Institute of Cancer and Blood Diseases, Hospital Clinic of Barcelona, Barcelona, Spain; Reveal Genomics, Barcelona, Spain. Electronic address:
Background: The infiltration of tumor-infiltrating B cells and plasma cells in early-stage breast cancer has been associated with a reduced risk of distant metastasis. However, the influence of B-cell tumor infiltration on overall patient survival remains unclear.
Materials And Methods: This study explored the relationship between an antitumor immune response, measured by a 14-gene B-cell/immunoglobulin (IGG) signature, and mortality risk in 9638 breast cancer patients across three datasets.
IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.
Tissue Cell
December 2024
Department of Pathology, The Fourth Hospital of Changsha, Changsha, Hunan 410006, PR China. Electronic address:
Background: Telomere maintenance is an important feature of tumor cells. Telomeric-repeat binding factor 1 interaction nuclear protein 2 (TIN2), a key member of the shelterin proteins, functions in regulating telomere structure, length and function. Our work sought to investigate the role of TIN2 in controlling gastric cancer (GC) malignant biological behaviors.
View Article and Find Full Text PDFNovel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement.
Ecotoxicol Environ Saf
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
This study aimed to investigate the potential of Pichia kudriavzevii (PK), a newly discovered yeast strain, in alleviating the deleterious effects induced by aflatoxins on broilers. Eighty one-day-old broiler chicks were divided into four groups and subjected to various combinations of aflatoxin dosages at 300 μg/kg of feed alongside PK supplementation at 1 g/kg of feed. Assessment encompassed a comprehensive array of parameters including performance metrics, hepatic and renal biomarkers, interleukin concentrations, blood cell counts, hemoglobin concentration, packed cell volume, antibody response to sheep red blood cells, lymphoproliferative response to PHA-P, phagocytic response utilizing the carbon clearance assay system, as well as evaluation of oxidants and antioxidants.
View Article and Find Full Text PDFAntioxidant treatment attenuates age-related placenta GLUT-1 and PLIN-2 downregulation.
Placenta
December 2024
Ageing and Stress Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal; Faculdade de Medicina Veterinária da Universidade Lusófona e Instituto Politécnico da Lusofonia, COFAC - Cooperativa de Formação e Animação Cultural, C.R.L., Campo Grande 376, 1749-024, Lisboa, Portugal; Escola Superior de Saúde, Politécnico do Porto, Rua Dr. António Bernardino de Almeida 400, 4200-072, Porto, Portugal. Electronic address:
Background And Aim: Pregnancy after the age of 35 is correlated with an increased risk of impaired placentation and the development of pregnancy-associated complications. Changes in uterine redox balance seem to play a role in these settings. In this work, we hypothesized that local redox dysregulation impacts the placenta metabolic profile.
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