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Genome Mining and Genetic Manipulation Reveal New Isofuranonaphthoquinones in Species.
Int J Mol Sci
August 2024
Department of Life Science and Biochemical Engineering, Institute of Biomolecule Reconstruction (iBR), Sun Moon University, Asan 31460, Republic of Korea.
Article Synopsis
- The study focuses on identifying specialized metabolites from microorganisms that could help in cancer treatment and combat multidrug-resistant pathogens, specifically through the analysis of naphthoquinones and their derivatives.
- Researchers discovered new furanonaphthoquinones (fnqs) with promising anticancer properties from the microorganism sp. CS682, showing lower toxicity compared to traditional naphthoquinones.
- The study utilized techniques like genome mining and CRISPR-Cas9 for gene editing, leading to the isolation and characterization of two compounds, NOC-IBR1 and NOC-IBR2, with NOC-IBR2 demonstrating greater biological activity through various assays.
New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.
J Antibiot (Tokyo)
April 2017
Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Isofuranonaphthoquinones (IFQs) and Isoindolequinones (IIQs) comprise a small family of natural products, with the latter ones are especially uncommon in nature. Here we report the discovery of seven new IFQs, IFQ A-G (1-7), and three new IIQs, IIQ A-C (8-10), along with the known anthraquinone desoxyerythrolaccin (11), from Streptomyces sp. CB01883, expanding the chemical diversity of this family of natural products.
View Article and Find Full Text PDFInvolvement of the Baeyer-Villiger Monooxygenase IfnQ in the Biosynthesis of Isofuranonaphthoquinone Scaffold of JBIR-76 and -77.
Chembiochem
June 2016
Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
JBIR-76 and -77 are isofuranonaphthoquinones (IFNQs) isolated from Streptomyces sp. RI-77. Draft genome sequencing and gene disruption analysis of Streptomyces sp.
View Article and Find Full Text PDFJBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77.
J Antibiot (Tokyo)
September 2016
National Institute of Advanced Industrial Science and Technology, Koto-ku, Japan.
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