Two new limonoids, named rubescins D-E (1-2) along with eight known compounds, including five havanensin type limonoids, TS1 (3), TS3 (4), rubescins A-C (5-7) and three known phytosterols, β-sitosterol, stigmasterol and its 3β-O-glucopyranoside derivative were isolated from the roots and stem bark of Trichilia rubescens, collected from Cameroon. The structures of the new compounds were determined by detailed analyses of 1D and 2D NMR spectra, in combination with high-resolution mass spectrometry data and by comparison with related data from literature. Anti-plasmodial activities of some of the isolated limonoids 1, 2, 4, 6 and 7 were evaluated against erythrocytic stages of strain 3D7 Plasmodium falciparum. Compounds 2 and 4 exhibited significant anti-plasmodial in vitro activity with IC50 values of 1.13 and 0.79 μM, respectively.
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Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
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a Faculty of Science, Department of Organic Chemistry , University of Yaounde I, Yaounde , Cameroon.
Article Synopsis
- Researchers isolated two new compounds, rubescins I and J, from the stem bark of the Trichilia rubescens tree, along with six already known compounds.
- The identified known compounds include rubescin D, lichexanthone, scopoletin, scopoletin O-glycoside, β-sitosterol, and stigmasterol.
- The structures of these compounds were analyzed using techniques like mass spectrometry (MS) and NMR, as well as comparisons with existing research.
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