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| http://dx.doi.org/10.1007/s12471-015-0790-6 | DOI Listing |
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Embedding a ribonuclease in the spore crust couples gene expression to spore development in Bacillus subtilis.
Nucleic Acids Res
January 2025
EGM CNRS, Université Paris-Cité,Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France.
Faced with nutritional stress, some bacteria form endospores capable of enduring extreme conditions for long periods of time; yet the function of many proteins expressed during sporulation remains a mystery. We identify one such protein, KapD, as a 3'-exoribonuclease expressed under control of the mother cell-specific transcription factors SigE and SigK in Bacillus subtilis. KapD dynamically assembles over the spore surface through a direct interaction with the major crust protein CotY.
View Article and Find Full Text PDFMyxomatous Mysteries: Decoding the Oral Focal Mucinosis.
Cureus
August 2024
Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences of Research, Kolkata, IND.
Oral focal mucinosis (OFM) is a unique benign lesion of the oral cavity with uncertain etiology which is analogous to cutaneous focal mucinosis. It mainly affects women in their fourth and fifth decades of life. The diagnosis of this condition is based on histopathological examination, as it lacks characteristic clinical and radiographic features.
View Article and Find Full Text PDFEnhancing emergency competencies in healthcare professionals via murder mystery games: An innovative gamification learning-based approach.
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December 2024
Henan Dongjin Information Technology Co., Ltd, Zhengzhou 450007, China.
Background: Enhancing the emergency competencies of healthcare professionals is essential for ensuring patient safety, optimizing emergency response efficiency, and fostering effective team collaboration. However, traditional simulation-based methods often struggle to accurately replicate real-life emergencies, resulting in outcomes that may not fully reflect actual performance, thereby undermining their effectiveness in training and developing the critical skills needed for emergency situations.
Objective: This study evaluated the effectiveness of using murder mystery games (MMGs) as a gamified learning method to enhance the emergency competencies of healthcare professionals.
Diagnostic and Therapeutic Roles of Extracellular Vesicles and Their Enwrapped ncRNAs in Rheumatoid Arthritis.
J Inflamm Res
August 2024
Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
Article Synopsis
- * Extracellular vesicles (EVs) play a critical role in facilitating communication between cells by transferring ncRNAs, which can influence the functions and activities of the recipient cells in RA.
- * The review explores the levels of EVs and their ncRNA content in RA patients, discusses relevant signaling pathways, and highlights the therapeutic potential of using exosomes for gene therapy in RA treatment.
Pitavastatin ameliorates myocardial injury by inhibiting myocardial inflammation and oxidative stress by modulating the microRNA-106B-5p/mitogen-activated protein kinase kinase kinase 2 axis.
J Physiol Pharmacol
June 2024
Department of Pharmacy Dispensing, The Fourth Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, 150001, China.
Myocarditis (MC) is a myocardial inflammatory disease that threats human life. Pitavastatin (Pit) is a unique lipophilic statin with potent effects on lowering plasma total cholesterol and triacylglycerols. It has been reported to have pleiotropic effects, such as reducing inflammation and oxidative stress.
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