Introduction: One of the characteristics of modern era is the explosion of diabetes in the world. Today more than 400,000,000 people suffer from diabetes in the entire world. During the last decade the number of women with the disorder of glucose homeostasis is six to seven times greater than in the previous period. Therefore, the re-evaluation of the impact of glucose intolerance on the course and outcome of pregnancy is very current.
Objective: The aim of the study was to evaluate the data on the influence of mothers' glucose homeostasis disturbances on the occurrence of cardiorespiratory disorders in newborns, as well as their influence on the perinatal outcome.
Methods: Prospective examination included 102 newborns in total - 31 infants of mothers with glucose homeostasis disorder (Group 1) and 71 infants of healthy mothers (Group II). Average age, body height, body weight, body mass index, parity and illness duration of the pregnant women had been determined, as well as the delivery method. Every newborn was provided with physical examination, Apgar score was calculated, body weight and body length were measured. Also, electrocardiography and brain ultrasound, as well as the basic hematology biochemical and microbiological analysis, were performed within the examinations of the infants.
Results: The average weight and obesity incidence with diabetic women was higher than in the control group and their infants were heavier and with lower gestational age. Heart failures were diagnosed in five (16.1%) infants of diabetic mothers and in one (1.4%) infant of a healthy woman (p<0.01). Respiratory disorders were diagnosed in 48.4% infants of diabetic mothers and in 12.6% of healthy mothers (p<0.01). Forty-two percent of infants of diabetic mothers and 19.7% infants of healthy mothers needed additional oxygen.
Conclusion: Congenital anomalies of the cardiovascular system and respiratory disorders in the infants of diabetic mothers were six to eight times more frequent than in the infants of healthy mothers.
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http://dx.doi.org/10.2298/sarh1510567h | DOI Listing |
BBA Adv
December 2024
Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
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Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
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Department of Endocrine Medicine, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201306, Chin, China.
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Department of Physiology, Pharmacology, and Toxicology, West Virginia University, Morgantown, WV, 26505, USA.
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View Article and Find Full Text PDFComput Biol Med
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University of Virginia, Center for Diabetes Technology, Charlottesville, VA, 22903, USA. Electronic address:
Diabetes presents a significant challenge to healthcare due to the short- and long-term complications associated with poor blood sugar control. Computer simulation platforms have emerged as promising tools for advancing diabetes therapy by simulating patient responses to treatments in a virtual environment. The University of Virginia Virtual Lab (UVLab) is a new simulation platform engineered to mimic the metabolic behavior of individuals with type 2 diabetes (T2D) using a mathematical model of glucose homeostasis in T2D and a large population of 6062 virtual subjects.
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