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Amyloid beta-activated alpha-1-syntrophin has ramifications on Rac1 activation, ROS production and neuronal cell death.
Eur J Neurosci
December 2024
Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the presence of β-amyloid (Aβ)-containing extracellular neuritic plaques and phosphorylated tau-containing intracellular neurofibrillary tangles. It remains the primary neuropathological criteria for the diagnosis of AD. Additionally, several other processes are currently being recognized as significant risk factors for AD development, including the brain's susceptibility to reactive oxygen species (ROS).
View Article and Find Full Text PDF4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms.
Neuropharmacology
June 2024
Department of Basic and Oral Biology, FORP, Campus USP, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:
Article Synopsis
- - The study tested two compounds, 4'-fluorocannabidiol (4'-F-CBD) and HU-910, to see if they could help with l-DOPA-induced dyskinesia (LID) by reducing striatal inflammation and correcting glutamate issues in mice with Parkinson's-like symptoms.
- - Results showed that only the combination of 4'-F-CBD and the TRPV1 antagonist capsazepine (CPZ) effectively reduced LID and normalized certain glutamate transporter markers, while HU-910 and other CB2 agonists were ineffective.
- - While both compounds lowered inflammation markers in the brain, they did not independently prevent LID, suggesting that anti-inflammatory properties alone are not enough
Association of healthy eating index and anthropometric indices among primary school girls in southeast of Iran: a cross-sectional study.
BMC Nutr
February 2024
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Background: The school-age period is marked by substantial advancements in physical and cognitive development, highlighting the importance of assessing the diet quality and its impact on body weight and height. The main objective of this study was to evaluate the association between diet quality and selected anthropometric indices of primary school girls in southeast of Iran using the healthy eating index-2015 (HEI-2015).
Methods: This cross-sectional study involved 330 students aged 6-12 years from 10 primary schools in Kerman City.
Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression.
Neuropharmacology
May 2024
Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address:
Delayed therapeutic responses and limited efficacy are the main challenges of existing antidepressant drugs, thereby incentivizing the search for new potential treatments. Cannabidiol (CBD), non-psychotomimetic component of cannabis, has shown promising antidepressant effects in different rodent models, but its mechanism of action remains unclear. Herein, we investigated the antidepressant-like effects of repeated CBD treatment on behavior, neuroplasticity markers and lipidomic profile in the prefrontal cortex (PFC) of Flinders Sensitive Line (FSL), a genetic animal model of depression, and their control counterparts Flinders Resistant Line (FRL) rats.
View Article and Find Full Text PDFDigging into the intrinsic capacity concept: Can it be applied to Alzheimer's disease?
Prog Neurobiol
March 2024
i+HeALTH Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC), 47012 Valladolid, Spain. Electronic address:
Article Synopsis
- Aging research mostly looked at diseases before, but now it's more about helping people age healthily.
- The World Health Organization (WHO) says we should focus on what older people can do and introduced a new idea called "intrinsic capacity" (IC), which looks at different aspects of health like movement and thinking.
- Our study tries to use the IC idea for Alzheimer's patients to improve how we diagnose and treat them by understanding how the brain and body work together.
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