The hydroalkylation of alkenes using alkyl iodides with Hantzsch ester as a hydrogen source occurred smoothly under a Pd/light system, in a novel, tin-free Giese reaction. A chemoselective reaction at C(sp(3))-I in the presence of a C(sp(2))-X (X = Br or I) bond was attained, which allowed for the stepwise functionalization of two types of C-X bonds in a one-pot procedure.
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| http://dx.doi.org/10.1021/acs.orglett.5b03238 | DOI Listing |
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