This study introduces the facile fabrication of a bimodal nanohybrid for the luminescent ON/OFF detection of glutathione. The proposed nanosensor consists of magnetic (Fe3O4) and upconversion nanoparticles (UCP) co-encapsulated in a silica matrix, and decorated with gold nanoparticle (AuNP) as a luminescent quencher. The detection mechanism is based on the Luminescent Resonance Energy Transfer (LRET) between the donor (UCP) and the acceptor (AuNP) with the help of a disulfide bond as a bridging element. In the presence of glutathione, the disulfide bridges between AuNPs and Fe3O4/UCP@SiO2 was cleaved and the amount of glutathione could be traced by the restored luminescence (ON state) of the nanohybrids after magnetic separation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1166/jnn.2015.11221 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Small upconversion-ruthenium nanohybrids for cancer theranostics.
Nanoscale
January 2025
McMaster University, Department of Engineering Physics, Hamilton, ON M8S 4K1, Canada.
Photoresponsive drug delivery systems have great potential for improved cancer therapy. However, most of the currently available drug-delivery nanosystems are relatively large and require light excitation with low tissue penetration. Here, we designed a near infrared responsive drug delivery system by loading [Ru(terpyridine)(dipyridophenazine)(HO)] (Ru(tpy)DPPZ) in azobenzene-modified mesoporous silica coated NaGdF:Nd/Yb/Tm upconversion nanoparticles (azo-mSiO-UCNPs).
View Article and Find Full Text PDFIntegrating All-rounder TiO Accelerated Electrochemiluminescence with Dual-Quenching PDA@COF Probes for Sensitive Quantification and Protein Profiling of Tumorous Exosomes.
ACS Appl Mater Interfaces
November 2024
Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Article Synopsis
- * The sensor utilizes a complex nanohybrid structure that enhances luminescence and effectively captures exosomes, while a modified framework helps control the signal for precise detection.
- * This method allows for sensitive detection of tumorous exosomes and their surface proteins, which could improve cancer diagnostics and monitoring.
Lanthanide-Doped Nanoparticles Anchoring on Metal-Organic Frameworks with Thermally Enhanced Upconversion Luminescence for Sensitive Nanothermometers.
ACS Appl Mater Interfaces
October 2024
State Key Laboratory of Silicon and Advanced Semiconductor Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310030, China.
Nanothermometers can detect changes in the local temperature in living cells and in vivo, revealing fundamental biological properties. Despite the exploration of different temperature-responsive materials, the design and development of temperature-sensing probes with high brightness and high sensitivity remain a daunting challenge. Here, we employed the UiO-66 type metal-organic frameworks (MOFs) to anchor UNCPs on the surface of the MOFs for constructing MOF@UCNPs nanohybrids.
View Article and Find Full Text PDFSustained antibacterial release of zwitterionic globular hyperbranched polymer dots intercalated into layered double hydroxides.
RSC Adv
October 2024
Department of Chemical Engineering, National Chung Hsing University 145 Xingda Rd., South Dist. Taichung 40227 Taiwan +886-4-22854734 +886-4-22853769.
Article Synopsis
- This study explores the development of zwitterionic hyperbranched polymer (HBP) dots integrated into layered double hydroxides (LDHs) for long-lasting antibacterial effects.
- The HBPs feature a unique spherical structure, with special blue luminescence, good water solubility, and various functional groups that help with antibacterial activity and intercalation into LDHs.
- X-ray diffraction and Fourier-transform infrared spectroscopy were used to confirm changes in layer spacing and the presence of functional groups, showing that the HBP/LDH hybrids can provide effective and controlled antibacterial release over time.
Phosphopeptide-bridged NH-TiO-mediated carbon dots self-enhancing and electrochemiluminescence microsensors for label-free protein kinase A detection.
Mikrochim Acta
September 2024
State Key Laboratory of Food Nutrition and Safety, Tianjin Economy and Technology Development Area, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin, 300457, P.R. China.
A novel electrochemiluminescence (ECL) method was developed for determination of protein kinase A (PKA) ultra-sensitively based on amidated nano-titanium (NH-TiO) embellished carbon dots (Mg@N-CDs) fluorescent probe, which integrated the target recognition and ECL signal enhancement. The Cys-labeled kemptides were employed to build a serine-rich synthetic substrate-heptapeptide (Cys-kemptide) on the Au-electrode surface. Then, the PKA-induced biosensor was triggered as a signal switch to introduce the large amounts of TiO decorated Mg@N-CD nanohybrid (Ti@NMg-CDs) into AuE/Cys-phosphopeptides for signal output.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!