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Repurposing of the analgesic Neurotropin for MASLD/MASH treatment.
Hepatol Commun
August 2024
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Background: The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased in recent decades. Approximately 25% of patients with MASLD progress to metabolic dysfunction-associated steatohepatitis, which is characterized by hepatic steatosis plus hepatocyte damage, inflammation, and fibrosis. We previously reported that Neurotropin (NTP), a drug used for relieving pain in Japan and China, inhibits lipid accumulation in hepatocytes by preventing mitochondrial dysfunction.
View Article and Find Full Text PDFNeurotropin alleviates cognitive impairment by inhibiting TLR4/MyD88/NF-κB inflammation signaling pathway in mice with vascular dementia.
Neurochem Int
December 2023
Special Medical Service Center, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, China. Electronic address:
Vascular dementia (VD) is the second most common cause of dementia after Alzheimer's disease. Neuroinflammation contributes to pathogenesis of VD. Neurotropin (NTP) is an analgesic that has been shown to suppress inflammation and neural repair.
View Article and Find Full Text PDFNeurotropin protects rotator cuff tendon cells from lidocaine-induced cell death.
Clin Shoulder Elb
December 2021
Department of Orthopedic Surgery, Kurume University Hospital, Fukuoka, Japan.
Background: Local anesthetics often are used in rotator cuff tears as therapeutic tools, although some cases have reported that they have detrimental effects. Neurotropin (NTP) is used widely in Japan as a treatment for various chronic pain conditions and is shown to have protective effects on cartilage and nerve cells. In this study, we investigated the protective effect of NTP against lidocaine-induced cytotoxicity.
View Article and Find Full Text PDFFluorocitrate and neurotropin confer analgesic effects on neuropathic pain in diabetic rats via inhibition of astrocyte activation in the periaqueductal gray.
Neurosci Lett
January 2022
Key Laboratory of Brain Science, Zunyi Medical University, No. 6 West Xuefu Road, Xinpu District, Zunyi, Guizhou, 563000, China; Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, No. 6 West Xuefu Road, Xinpu District, Zunyi, Guizhou 563000, China. Electronic address:
Article Synopsis
- Effective treatments for diabetic neuropathic pain (DNP) are lacking, prompting research into the role of astrocyte activation in pain regulation.
- The study tested fluorocitrate (FC), an astrocyte activation inhibitor, and neurotropin, a common analgesic, in a rat model of DNP to see if they could reduce pain by inhibiting astrocyte activation in the brain's ventrolateral periaqueductal gray (vlPAG).
- Results showed that both FC and neurotropin improved pain responses by lowering mechanical withdrawal thresholds and reducing astrocyte activation markers in DNP-affected rats, indicating potential treatment strategies for managing DNP.
Acetaminophen Exerts an Analgesic Effect on Muscular Hyperalgesia in Repeated Cold-Stressed Rats through the Enhancement of the Descending Pain Inhibitory System Involving Spinal 5-HT and Noradrenergic α Receptors.
Biol Pharm Bull
August 2021
Self-Medication R&D Laboratories, Taisho Pharmaceutical Co., Ltd.
Musculoskeletal and psychological complaints have increased with the widespread use of visual display terminals, and musculoskeletal pain is known to be closely related to stress. One method of experimentally inducing persistent muscle pain is repeated cold stress (RCS), and animals exposed to such stress exhibit a dysfunction in the descending pain inhibitory system. Acetaminophen (N-acetyl-p-aminophenol; APAP) is widely used to relieve several types of pain, including musculoskeletal pain, and is available as an OTC drug.
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